Clinical Report: Effectiveness and Safety of Porcine Fibrin Sealant in VATS Lobectomy

Overview

This study evaluates the safety and clinical efficacy of porcine fibrin sealant (PFS) in video-assisted thoracoscopic lobectomy for lung cancer. Results indicate that PFS application is associated with a reduction in the duration of chest tube placement and the incidence of pulmonary air leaks.

Background

Lung cancer is the leading cause of cancer-related mortality globally, and postoperative complications such as pleural effusion and pulmonary air leaks pose significant challenges. Minimally invasive techniques have improved surgical outcomes, yet complications still prolong recovery and increase patient burden. The use of biological sealants like PFS may offer a solution to mitigate these issues, as suggested by previous studies.

Data Highlights

Key Findings

• PFS application was associated with a reduction in the duration of chest tube placement (P = 0.036).
• PFS reduced the incidence of pulmonary air leaks to 0.0% compared to 5.0% in the control group (P = 0.019).
• There was a significant reduction in severely prolonged drainage (0.0% vs. 22.3%, P < 0.001).
• No significant differences in other complications were observed.
• The study included 345 patients, divided into a PFS group (n = 203) and a control group (n = 142).

Clinical Implications

The findings suggest that PFS application during VATS lobectomy is associated with a reduction in the duration of chest tube placement and pulmonary air leaks.

Conclusion

The study indicates that the intraoperative application of PFS during VATS lobectomy is associated with reduced postoperative complications.

Related Resources & Content

1. Frontiers in Surgery, 2026 -- Clinical Efficacy and Safety of Porcine Fibrin Sealant in Video-Assisted Thoracoscopic Surgery Lobectomy for Lung Cancer
2. Surgical Endoscopy — Evaluation of LigaSure™ Bipolar Vessel Sealer Versus Monopolar Electrocoagulation in Thoracoscopic Lobectomy and Lymphadenectomy: A Prospective Randomized Controlled Study
3. Frontiers in Surgery — Clinical efficacy and safety of different video-assisted thoracoscopic surgery approaches for bullous lung resection: a systematic review and meta-analysis
4. the asco post — Overall Survival Risk for VATS vs Open Lobectomy for Early Lung Cancer
5. Evaluating the Viability and Benefits of Subxiphoid Uniportal Video-Assisted Thoracoscopic Surgery for Pulmonary Lobectomy
6. Recommendations for the standardization and management of prolonged air leaks in lung surgery
7. Clinical efficacy of surgical sealants after pulmonary resection: an individual patient data meta-analysis of randomized controlled trials
8. Efficacy of fibrin sealant for bedside pleurodesis in patients with prolonged air leak after lung cancer surgery: a comparative study
9. Frontiers | Clinical Efficacy and Safety of Porcine Fibrin Sealant in Video-Assisted Thoracoscopic Surgery Lobectomy for Lung Cancer