Clinical correlates and cognitive associations of the neutrophil-to-lymphocyte ratio in first-episode psychosis and at-risk mental states - Report - MDSpire
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Clinical correlates and cognitive associations of the neutrophil-to-lymphocyte ratio in first-episode psychosis and at-risk mental states
Clinical Report: Associations Between Neutrophil-to-Lymphocyte Ratio and Cognitive Function
Overview
This study examines the neutrophil-to-lymphocyte ratio (NLR) in individuals with first-episode psychosis (FEP), clinical high-risk for psychosis (CHR-P), and healthy controls. No significant differences in NLR were found among the groups.
Background
Understanding immune alterations in psychosis is crucial as they may precede treatment initiation and impact clinical outcomes. The neutrophil-to-lymphocyte ratio (NLR) serves as a potential marker of systemic inflammation.
Data Highlights
No significant differences in NLR were observed between FEP, CHR-P, and HC groups (F = 1.04; p=0.36).
Key Findings
No significant differences in NLR among FEP, CHR-P, and HC groups.
In FEP, NLR positively correlated with higher levels of positive symptoms (b2=0.035; p=0.01).
In FEP, NLR positively correlated with longer duration of untreated psychosis (b2=0.003; p=0.04).
In CHR-P, NLR negatively correlated with antidepressant use (b2=-0.664; p=0.02).
No significant associations between NLR and neurocognitive performance or antipsychotic treatment in any group.
Clinical Implications
The findings suggest that while NLR may not serve as a diagnostic biomarker in early psychosis, it could reflect inflammatory status related to symptom severity in FEP. Further research is warranted to explore the dynamics of NLR in larger samples.
Conclusion
The study indicates that NLR does not differentiate between psychosis stages but may correlate with symptom severity in FEP. Continued investigation into NLR's role in psychosis is necessary.
by Clàudia Aymerich, Borja Pedruzo, Garazi Acasuso, Olatz Ibarretxe, Daniel Alonso-Alconada, Javier Labad, Maria José Algora, Ángel Cabezas, Gonzalo Salazar de Pablo, Miguel Ángel González-Torres, Vanessa Sanchez-Gistau, Ana Catalán
