Application of transvaginal color doppler ultrasound in early diagnosis of threatened abortion and its correlation with serum levels of β - hCG and CA125 - Report - MDSpire

Application of transvaginal color doppler ultrasound in early diagnosis of threatened abortion and its correlation with serum levels of β - hCG and CA125

  • By

  • Li Cao

  • Hongbing Xiang

  • Dongfang Ren

  • Jinsheng Li

  • July 15, 2026

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Utilization of Transvaginal Color Doppler Ultrasound for Early Detection of Threatened Abortion

Overview

This study evaluates the effectiveness of transvaginal color Doppler ultrasound (TVCDS) combined with serum β-hCG and CA125 levels in diagnosing threatened abortion.

Background

Threatened abortion is a significant concern in early pregnancy, with a high incidence of miscarriage. Accurate diagnosis and prediction of pregnancy outcomes are crucial for managing patient care.

Data Highlights

ParameterObservation GroupControl Group
Corpus Luteum PIHigherLower
Corpus Luteum RIHigherLower
CA125HigherLower
β-HCGLowerHigher
TVCDS Sensitivity92.86%N/A
TVCDS Specificity100%N/A
AUC of Combined Predictor0.931N/A

Key Findings

  • TVCDS demonstrated 92.86% sensitivity and 100% specificity in diagnosing threatened abortion.
  • The observation group had significantly higher corpus luteum pulsatility index (PI) and resistance index (RI) compared to the control group.
  • Serum CA125 levels were elevated in the observation group, while β-HCG levels were lower.
  • Corpus luteum PI and RI were negatively correlated with β-HCG and positively correlated with CA125.
  • The combined predictive model using PI, β-HCG, and CA125 yielded an AUC of 0.931, indicating superior predictive capability.

Clinical Implications

The findings indicate the potential for improved diagnostic processes for threatened abortion.

Conclusion

The integration of transvaginal color Doppler ultrasound with serum β-HCG and CA125 levels provides a method for diagnosing threatened abortion.

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  2. Archives of Gynecology and Obstetrics, 2026 -- Transvaginal ultrasonographic characteristics of different types of residual pregnancy tissue in patients with incomplete medication abortion
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