Clinical manifestations and outcomes of fetal periventricular pseudocysts: a study of 38 cases - Report - MDSpire

Clinical manifestations and outcomes of fetal periventricular pseudocysts: a study of 38 cases

  • By

  • Jing Ding

  • YiHan Xiao

  • Jie Fu

  • Jia Liu

  • Yifang Yuan

  • Qiuyan Pei

  • July 13, 2026

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Clinical Features and Prognostic Outcomes of Fetal Periventricular Pseudocysts

Overview

This study analyzes 38 cases of fetal periventricular pseudocysts, highlighting their clinical features and outcomes. Most cases were diagnosed in the third trimester, with a majority being bilateral.

Background

Fetal periventricular pseudocysts (PVPCs) are fluid-filled cavities adjacent to brain ventricles, often detected via advanced imaging techniques. Understanding their clinical significance and outcomes is crucial for managing prenatal care and addressing parental concerns regarding prognosis. Further investigation into the characteristics and implications of these lesions is necessary.

Data Highlights

CharacteristicValue
Total cases38
Diagnosed in second trimester5
Diagnosed in third trimester33
Therapeutic abortions3
Term deliveries33
Preterm deliveries2
Average gestational age at diagnosis (weeks)31.4
Bilateral pseudocysts25
Newborns with developmental delays2

Key Findings

  • Most fetal periventricular pseudocysts were diagnosed in the third trimester.
  • Over two-thirds of the pseudocysts were bilateral.
  • The lateral aspect of the anterior horn of the lateral ventricle was the primary site of occurrence.
  • 15 of the 38 pseudocysts showed variable changes in size during pregnancy.
  • Three fetuses had genetic or chromosomal abnormalities detected during pregnancy.
  • Two newborns required NICU admission due to infection and prematurity.

Clinical Implications

Clinicians should provide thorough counseling to expectant parents regarding the implications of the diagnosis, particularly in cases with additional abnormalities.

Conclusion

Fetal periventricular pseudocysts are predominantly diagnosed in later pregnancy stages, with a significant proportion being bilateral.

Related Resources & Content

  1. Pediatric Cardiology, Source, Year -- Prenatal Identification of Isolated Persistent Left Superior Vena Cava with Absent Right Superior Vena Cava: A Case Series
  2. Outcomes of Posterior Fossa Arteriovenous Malformations: Insights from a Single-Center Study, Source, Year
  3. Open Forum Infectious Diseases, Source, Year -- Clinical Features of Patients Diagnosed with Patent Foramen Ovale and Pyogenic Brain Abscess
  4. European Radiology, Source, Year -- Does isolated ventriculomegaly influence choroid plexus development as observed through fetal neuro-ultrasound?
  5. ISUOG Practice Guidelines (updated), Source, Year -- performance of fetal magnetic resonance imaging
  6. Society for Maternal-Fetal Medicine Consult Series #45, Source, Year -- Mild fetal ventriculomegaly: diagnosis, evaluation, and management
  7. Fetal periventricular pseudocysts: is MRI evaluation needed? What is the long-term neurodevelopmental outcome? Systematic review and meta-analysis, Source, Year
  8. ISUOG Practice Guidelines (updated): performance of fetal magnetic resonance imaging - PMC
  9. Society for Maternal-Fetal Medicine Consult Series #45: Mild fetal ventriculomegaly: diagnosis, evaluation, and management - SMFM Publications and Clinical Guidelines
  10. Fetal periventricular pseudocysts: is MRI evaluation needed? What is the long-term neurodevelopmental outcome? Systematic review and meta-analysis - PubMed

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