Examining the Link Between a Modified Cardiometabolic Index and Cardiovascular Disease Risk in Adults with Early Cardiovascular-Kidney-Metabolic Syndrome: Findings from a Prospective Cohort Study - Report - MDSpire

Examining the Link Between a Modified Cardiometabolic Index and Cardiovascular Disease Risk in Adults with Early Cardiovascular-Kidney-Metabolic Syndrome: Findings from a Prospective Cohort Study

  • By

  • Hongcai Wang

  • Kaixuan Li

  • Chang Sheng

  • Xin Ye

  • Guoqiang Lin

  • March 13, 2026

  • 0 min

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Clinical Report: Examining the Link Between a Modified Cardiometabolic Index

Overview

This study investigates the association between the modified cardiometabolic index (MCMI) and cardiovascular disease (CVD) risk among adults with early cardiovascular-kidney-metabolic syndrome. Findings indicate that MCMI is a significant predictor of CVD incidence in this population.

Background

The rising prevalence of type 2 diabetes, cardiovascular disease, and chronic kidney disease poses a significant public health challenge. These conditions are interrelated, with metabolic abnormalities serving as critical risk factors. Understanding the associations between these diseases is essential for developing effective prevention strategies.

Data Highlights

No numerical data available in the provided material.

Key Findings

  • MCMI is identified as an independent risk factor for CVD in patients with CKM (HR: 1.07, p = 0.006).
  • The study utilized data from the China Health and Retirement Longitudinal Study (CHARLS) involving 6,953 participants.
  • Participants were screened for CKM syndrome stages 0–3, emphasizing the importance of early detection.
  • Metabolic abnormalities such as insulin resistance and inflammation are prevalent risk factors for CKD and CVD.
  • The AHA highlights the need for systematic screening in the preclinical phase of CKM.

Clinical Implications

Healthcare professionals should consider the MCMI as a valuable tool for assessing cardiovascular risk in patients with early CKM syndrome. Early identification and intervention may reduce the incidence of CVD in this high-risk population.

Conclusion

The findings underscore the importance of the MCMI in predicting cardiovascular risk among adults with early CKM syndrome, supporting the need for early screening and intervention strategies.

References

  1. European Journal of Preventive Cardiology, 2023 -- Cardiovascular–kidney–metabolic syndrome and mortality in a prospective UK cohort study
  2. The Journal of Clinical Endocrinology & Metabolism, 2023 -- Associations of Metabolic Phenotypes with Cardiac Structure and Clinical Outcomes: Insights from the UK Biobank
  3. The Journal of Clinical Endocrinology & Metabolism, 2023 -- Links Between Visceral and Hepatic Fat with Cardiac Structure and Function: Findings from a UK Biobank Analysis
  4. European Journal of Preventive Cardiology, 2023 -- Gender Variations in Cardiovascular–Kidney–Metabolic Risk Factors Linked to Degenerative Valvular Heart Disease
  5. Cardiovascular-Kidney-Metabolic Health | American Heart Association
  6. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2026 - PMC
  7. The modified cardiometabolic index as a simple screening tool for cardiovascular disease risk: a cohort study | Scientific Reports
  8. Cardiovascular-Kidney-Metabolic Health | American Heart Association
  9. 10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2026 - PMC
  10. The modified cardiometabolic index as a simple screening tool for cardiovascular disease risk: a cohort study | Scientific Reports

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