Effects of Malnutrition Assessment via PG-SGA on Clinical Outcomes in Patients with Advanced Gastrointestinal Cancers: A Retrospective Cohort Analysis - Report - MDSpire

Effects of Malnutrition Assessment via PG-SGA on Clinical Outcomes in Patients with Advanced Gastrointestinal Cancers: A Retrospective Cohort Analysis

  • By

  • Pei Zhuang

  • Jun-xuan Chen

  • Bing Xia

  • Xiao-su Chen

  • Xiao-tian Chen

  • Li Li

  • Ting Zhu

  • Shu-an Wang

  • Qing-yan Li

  • October 27, 2025

  • 0 min

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Clinical Report: Effects of Malnutrition Assessment via PG-SGA on Outcomes

Overview

This study evaluates the impact of malnutrition assessment using the PG-SGA tool on clinical outcomes in patients with advanced gastrointestinal cancers. It highlights the correlation between nutritional risk and overall survival, emphasizing the need for routine nutritional monitoring in oncology care.

Background

Malnutrition is a prevalent issue among cancer patients, significantly affecting treatment outcomes and survival rates. The PG-SGA tool offers a validated method for assessing nutritional status, which is crucial for identifying patients at risk and implementing timely interventions. Understanding the relationship between malnutrition and survival can enhance personalized treatment strategies in oncology.

Data Highlights

No numerical data available in the provided source material.

Key Findings

  • Malnutrition affects 25%–70% of cancer patients, with significant implications for survival.
  • Patients with intermediate/high malnutrition risk (PG-SGA >3) have worse overall survival compared to low-risk patients (adjusted HR = 1.98).
  • Subgroup analysis indicates a pooled HR of 1.61 for increased mortality risk in gastrointestinal cancers.
  • Dynamic nutritional risk assessment can provide independent prognostic information regarding overall survival.
  • Early nutritional intervention has been shown to improve survival rates in malnourished gastric cancer patients by 23%.

Clinical Implications

Routine assessment of nutritional status using PG-SGA should be integrated into standard oncology care for patients with advanced gastrointestinal cancers. Early identification and intervention for malnutrition can significantly improve patient outcomes and survival rates.

Conclusion

The findings underscore the importance of continuous nutritional monitoring and intervention in cancer care, particularly for patients with advanced gastrointestinal malignancies. Implementing PG-SGA assessments can lead to better-informed treatment strategies and improved survival outcomes.

References

  1. Author(s)/Org, Source, Year -- Title
  2. BJS (British Journal of Surgery), 2023 -- Multicentre prospective study on the diagnostic and prognostic validity of malnutrition assessment tools in surgery
  3. Journal of Neuro-Oncology, 2025 -- Exploring the Impact of Nutritional Choices on Treatment Outcomes and Toxicity in Glioblastoma Patients: A Retrospective Cohort Analysis
  4. Journal of Gastroenterology, 2024 -- Effects of Pancreatic Duct Blockage on Surgical Results in Patients with Pancreatic Head Cancer Receiving Neoadjuvant Treatment
  5. GLIM consensus approach to diagnosis of malnutrition: A 5‐year update - PMC, 2025
  6. GLIM consensus approach to diagnosis of malnutrition: A 5‐year update - PMC
  7. https://apjcn.qdu.edu.cn/2024-0407-online.pdf
  8. Ponsegromab for the Treatment of Cancer Cachexia - PubMed

Original Source(s)

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