Pagetoid reticulosis (Woringer–Kolopp disease) mimicking eczema: a case report with immunophenotypic analysis and literature review - Report - MDSpire

Pagetoid reticulosis (Woringer–Kolopp disease) mimicking eczema: a case report with immunophenotypic analysis and literature review

  • By

  • Yansi Lyu

  • Zonghua Wen

  • Jiefeng Jiang

  • Lyuxin Guan

  • Ziqin Gan

  • Maomao An

  • Suchun Hou

  • June 30, 2026

  • 0 min

Share

Clinical Report: Pagetoid Reticulosis Presenting as Eczema

Background

Pagetoid reticulosis is a rare subtype of cutaneous T-cell lymphoma that often mimics inflammatory skin conditions, leading to misdiagnosis and delayed treatment. Its clinical presentation as a solitary plaque can be mistaken for eczema or psoriasis.

Data Highlights

No numerical data or trial data available in the article.

Key Findings

  • Pagetoid reticulosis often presents as a solitary, well-demarcated plaque, typically on acral sites.
  • Histopathological analysis reveals epidermotropism of atypical lymphocytes with a pagetoid distribution.
  • Immunohistochemistry shows T-cell lineage with significant loss of CD4, CD7, and predominantly absent CD2/CD8 expression.
  • A Ki-67 proliferation index of approximately 40% and focal CD30 positivity are observed.
  • Localized forms of Woringer–Kolopp disease generally have a favorable prognosis.

Clinical Implications

Clinicians should maintain a high index of suspicion for Pagetoid reticulosis in patients with treatment-refractory acral plaques.

Conclusion

Pagetoid reticulosis can easily be misdiagnosed due to its clinical similarities with eczema.

Related Resources & Content

  1. Frontiers | Pagetoid Reticulosis (Woringer–Kolopp Disease) Mimicking Eczema: A Case Report with Immunophenotypic Analysis and Literature Review
  2. S2k‐Guidelines – Cutaneous lymphomas (ICD10 C82 ‐ C86): Update 2021
  3. Blood Cancer Journal — Dermatological Symptoms Associated with Monoclonal Gammopathy
  4. Infection — Eosinophilic Pustular Folliculitis Observed in a Female Patient with HIV Infection
  5. Frontiers in Medicine — Acquired reactive perforating collagenosis in a patient with multiple comorbidities: a case report from Palestine
  6. International Journal of Infectious Diseases — Necrotic Steroid-Dependent Erythema Nodosum Leprosum Mimicking Vasculitis in Multibacillary Leprosy with Negative Bacilloscopy: A Diagnostic Challenge
  7. Frontiers | Pagetoid Reticulosis (Woringer–Kolopp Disease) Mimicking Eczema: A Case Report with Immunophenotypic Analysis and Literature Review
  8. S2k‐Guidelines – Cutaneous lymphomas (ICD10 C82 ‐ C86): Update 2021
  9. ISCL/EORTC-CLTG/USCLC recommendations for the diagnosis, staging and treatment of early-stage paediatric mycosis fungoides: a modified Delphi consensus. Part one: diagnosis and staging - PubMed
  10. Cutaneous Lymphoma - EORTC

Original Source(s)

Pagetoid reticulosis (Woringer–Kolopp disease) mimicking eczema: a case report with immunophenotypic analysis and literature review

  • by Yansi Lyu, Zonghua Wen, Jiefeng Jiang, Lyuxin Guan, Ziqin Gan, Maomao An, Suchun Hou

  • June 30, 2026

Related Content

Fractionated stereotactic radiotherapy (fSRT) for symptomatic WHO grade 1 cavernous sinus meningiomas: long-term local control, clinical response, and toxicity outcomes

Mixed adenoneuroendocrine carcinoma of the gallbladder: a case report and literature review

Network analysis of distress, symptom burden, social support, and digital health literacy in older postoperative patients with gastric cancer