Integrated multi-omics identifies CRP as a prognostic biomarker and reveals complement consumption in HIV-associated AECOPD - Report - MDSpire

Integrated multi-omics identifies CRP as a prognostic biomarker and reveals complement consumption in HIV-associated AECOPD

  • By

  • Tao Qin

  • Wenlong Huang

  • Changwei Yang

  • Tianming Lu

  • Jun Wang

  • Jie Chen

  • Linli Chen

  • Tianyu Yan

  • Tingting Qian

  • Hao Yang

  • Linke Lu

  • Defa Huang

  • Minghong Zhao

  • June 19, 2026

  • 0 min

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Clinical Report: Multi-Omics Approach Identifies CRP as a Prognostic Indicator

Overview

This study identifies C-reactive protein (CRP) as a significant prognostic biomarker for short-term outcomes in patients with HIV-associated acute exacerbation of chronic obstructive pulmonary disease (HIV-AECOPD). The research highlights unique immunometabolic changes in this population.

Background

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality globally, with acute exacerbations (AECOPD) significantly impacting patient outcomes. Individuals with HIV are at an increased risk for developing COPD and experiencing more severe exacerbations.

Data Highlights

BiomarkerMean Decrease GiniAUC (95% CI)
CRP1.330.8125 (0.628–0.997)

Key Findings

  • CRP was identified as the most important predictor of poor 3-month prognosis in HIV-AECOPD.
  • The study utilized a multi-omics approach to reveal a unique serum profile in HIV-AECOPD, including complement activation and metabolic reprogramming.
  • Validation assays were conducted on six candidate biomarkers, confirming CRP's predictive value.
  • HIV infection is an independent risk factor for COPD development and exacerbations.
  • Approximately 46% of COPD patients experience at least one exacerbation annually, with significant implications for morbidity and mortality.

Clinical Implications

The identification of CRP as a prognostic biomarker may assist in risk-stratifying patients with HIV-AECOPD.

Conclusion

This study identifies CRP as a prognostic indicator in HIV-AECOPD.

Related Resources & Content

  1. The Journal of Infectious Diseases, 2023 -- A Biomarker Profile Reflective of Preserved Thymic Function Is Associated With Reduced Comorbidities in Aging People With HIV: An AGEhIV Cohort Analysis
  2. Frontiers in Immunology, 2026 -- Expression characteristics of C-reactive protein in autoimmune diseases and their complications
  3. 2026 GOLD Report and Pocket Guide - Global Initiative for Chronic Obstructive Lung Disease - GOLD
  4. Chronic Obstructive Pulmonary Disease in People with HIV: an Evidence-Based Review - PMC
  5. Frontiers in Endocrinology — Retraction: Integrated multi-omics analysis reveals complement component 3 as a central driver of immune dysregulation in polycystic ovary syndrome
  6. Frontiers in Immunology — Complement activation in patients with post-acute sequelae after SARS-CoV-2 infection
  7. 2026 GOLD Report and Pocket Guide - Global Initiative for Chronic Obstructive Lung Disease - GOLD
  8. Inflammatory Response in Exacerbations of COPD: Clinical and Predictive Roles of C-Reactive Protein - PubMed
  9. Chronic Obstructive Pulmonary Disease in People with HIV: an Evidence-Based Review - PMC

Original Source(s)

Integrated multi-omics identifies CRP as a prognostic biomarker and reveals complement consumption in HIV-associated AECOPD

  • by Tao Qin, Wenlong Huang, Changwei Yang, Tianming Lu, Jun Wang, Jie Chen, Linli Chen, Tianyu Yan, Tingting Qian, Hao Yang, Linke Lu, Defa Huang, Minghong Zhao

  • June 19, 2026

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