Global, regional, and national burden of disease for high BMI-related ischemic stroke in people aged 70 and older: trend analysis from 1990 to 2021 and projections for 2044 - Report - MDSpire

Global, regional, and national burden of disease for high BMI-related ischemic stroke in people aged 70 and older: trend analysis from 1990 to 2021 and projections for 2044

  • By

  • Zhendong Huang

  • Yu Min

  • Guowen Zhang

  • Ji Li

  • May 22, 2026

  • 0 min

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Clinical Report: High BMI-Related Ischemic Stroke in Older Adults

Overview

This report analyzes the global, regional, and national impact of high BMI-related ischemic stroke (HB-IS) in individuals aged 70 and above from 1990 to 2021, with projections for 2044. It highlights significant disparities in death rates and disability-adjusted life years (DALYs) across different socio-demographic indices (SDIs) and age groups.

Background

Ischemic stroke is a leading cause of mortality and disability, particularly in older adults, where high BMI has emerged as a significant risk factor. Understanding the burden of HB-IS in this demographic is crucial for targeted prevention strategies and healthcare planning. The study addresses the gaps in knowledge regarding the heterogeneity of HB-IS among older adults, emphasizing the need for tailored interventions.

Data Highlights

YearDeathsDALY Rates (per 100,000)
199055,30252.32
202183,0072085.76
Projected 2044104,638N/A

Key Findings

  • Death rates from HB-IS in 2021 ranged from 3.93 to 124.33 per 100,000 individuals aged ≥70 years.
  • DALY rates showed a global decline, primarily in high-SDI regions, while low and low-middle SDI regions experienced increases or stagnation.
  • Deaths from HB-IS increased from 55,302 in 1990 to 83,007 in 2021.
  • Future projections indicate deaths could reach 104,638 by 2044, with a concentration in those aged ≥80 years.
  • There are marked disparities in HB-IS burden based on geographic, SDI, sex, and age factors.

Clinical Implications

Healthcare providers should recognize the increasing burden of HB-IS in older adults, particularly in lower-SDI regions. Tailored prevention and management strategies that consider age, sex, and socio-demographic factors are essential for effective intervention. Weight management should be emphasized as part of comprehensive stroke prevention efforts.

Conclusion

The findings underscore the need for targeted strategies to address the rising burden of HB-IS among older adults, particularly as population aging continues. Continued monitoring and tailored interventions are critical to mitigate the impact of high BMI on ischemic stroke outcomes.

Related Resources & Content

  1. Global Burden of Disease Study 2021, 2021 -- Assessment of High BMI-Related Ischemic Stroke
  2. European Journal of Preventive Cardiology — Temporal trend and attributable risk factors of cardiovascular disease burden for adults 55 years and older in 204 countries/territories from 1990 to 2021: an analysis for the Global Burden of Disease Study 2021
  3. Worldwide Impact of Metabolic Risk Factors on Colorectal Cancer from 1990 to 2021, Including Mortality Forecasts for 2035
  4. The Impact of Elevated Body Mass Index on Colorectal Cancer in China: Analysis from 1990 to 2021 and Projections for 2035
  5. European Journal of Preventive Cardiology — The Prospects of Cardiovascular Disease: A Turning Point or Continued Challenge?
  6. 2024 Guideline for the Primary Prevention of Stroke
  7. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes
  8. Cardiovascular Effects and Tolerability of GLP-1 Receptor Agonists: A Systematic Review and Meta-Analysis of 99,599 Patients | JACC

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