Clinical Report: Stratified Analysis of Two Innovative Metabolism-Related Indices for Stroke Prediction in Patients with Mild Cognitive Impairment

Overview

This study evaluates the predictive value of the C-reactive protein-triglyceride glucose index (CTI) and the Body Roundness Index (BRI) for new-onset stroke in patients with mild cognitive impairment (MCI). Findings indicate that CTI is significantly associated with increased stroke risk, while BRI shows no significant correlation.

Background

Stroke is a major global health issue, particularly among patients with mild cognitive impairment (MCI), who are at heightened risk for cerebrovascular events. Identifying reliable predictive indicators for stroke in this population is crucial for effective primary prevention strategies. Metabolic disorders are known risk factors for both cognitive decline and stroke.

Data Highlights

Key Findings

• CTI is associated with a 34% higher risk of stroke per unit increase among MCI patients.
• BRI does not show a significant correlation with stroke occurrence.

Clinical Implications

Clinicians should consider incorporating CTI assessments into routine evaluations for stroke prevention strategies in this population.

Conclusion

CTI demonstrates a stronger predictive value for stroke risk compared to BRI in patients with MCI.

Related Resources & Content

1. Frontiers in Neurology, 2026 -- Cardiometabolic index and modified cardiometabolic index are associated with early neurological deterioration in patients with acute ischemic stroke
2. Frontiers in Neurology, 2026 -- Cardiometabolic Index: a novel prognostic biomarker for recurrent stroke risk in acute ischemic stroke patients
3. Frontiers in Cardiovascular Medicine, 2026 -- Identification of key metabolic indicators associated with the comorbidity of ischemic stroke and diabetes mellitus using an optimal interpretable clinlabomics model
4. Clinical Research in Cardiology, 2025 -- The Role of Prediabetes in Acute Stroke: Frequency and Influence on Initial Clinical Outcomes
5. 2024 Guideline for the Primary Prevention of Stroke: A Guideline From the American Heart Association/American Stroke Association
6. 2024 Guideline for the Primary Prevention of Stroke: A Guideline From the American Heart Association/American Stroke Association
7. https://cardiab.biomedcentral.com/counter/pdf/10.1186/s12933-025-02827-0.pdf
8. Vascular Contributions to Cognitive Impairment and Dementia in the United States: Prevalence and Incidence: A Scientific Statement From the American Heart Association - PubMed