Clinical Report: Investigation of Misdiagnosis in Pancreatic Acinar Cell Carcinoma

Background

Acinar cell carcinoma (ACC) is a rare pancreatic tumor that often presents with nonspecific symptoms, leading to diagnostic challenges. The condition is particularly difficult to differentiate from other pancreatic neoplasms, such as SPN and pancreatic ductal adenocarcinoma (PDAC). Elevated serum AFP levels, although uncommon, can indicate ACC and should be considered in the diagnostic process.

Data Highlights

Case report of a 72-year-old female with ACC:

• Serum AFP level: 2321.18 ng/mL
• Imaging: Mass in pancreatic head, normal liver
• Final diagnosis: Confirmed ACC post-surgery

Key Findings

• ACC accounts for approximately 1% of all pancreatic tumors.
• Elevated serum AFP levels can serve as a potential indicator of ACC.
• Imaging findings of ACC can resemble those of PDAC and SPN, increasing misdiagnosis risk.
• Radical surgery remains the primary treatment modality for ACC.

Clinical Implications

Healthcare professionals should consider elevated serum AFP levels in patients with pancreatic masses, as this may indicate ACC rather than other neoplasms. A multidisciplinary approach is essential to minimize diagnostic errors and improve patient outcomes.

Conclusion

This case highlights the importance of recognizing elevated AFP levels as a diagnostic clue for ACC, which can prevent misdiagnosis and ensure appropriate surgical intervention.

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