Clinical Report: Linking Heavy Metals and Essential Trace Elements in Follicular Fluid to Reduced Ovarian Reserve

Overview

This study investigates the association between heavy metals and essential trace elements in follicular fluid and diminished ovarian reserve (DOR). Significant findings indicate that higher concentrations of arsenic, strontium, and calcium in follicular fluid are linked to increased odds of DOR.

Background

Diminished ovarian reserve (DOR) is a significant factor contributing to infertility, affecting approximately 10% of infertile populations. The etiology of DOR is multifactorial, involving genetic, metabolic, and environmental influences.

Data Highlights

Key Findings

• FF concentrations of arsenic, strontium, and calcium were significantly higher in the DOR group.
• Logistic regression indicated that arsenic and strontium were associated with higher odds of DOR.
• Copper, vanadium, and zinc were associated with lower odds of DOR.
• The weighted quantile sum regression identified strontium, arsenic, and calcium as primary contributors to DOR risk.

Clinical Implications

Clinicians should consider the potential impact of environmental heavy metals and trace elements on ovarian reserve when evaluating infertility.

Conclusion

The study highlights the association between heavy metals and essential trace elements in follicular fluid and diminished ovarian reserve.

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5. Exposure to heavy metallic and trace essential elements and risk of diminished ovarian reserve in reproductive age women: A case-control study - ScienceDirect
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