Clinical Report: Experience with Interventional Treatment for CPSS in Children

Overview

This study evaluates the safety and short-term efficacy of interventional therapy for congenital portosystemic shunt (CPSS) in pediatric patients. A total of 26 children were treated, achieving a 73% overall success rate with minimal complications.

Background

Congenital portosystemic shunts (CPSS) are rare vascular malformations that can lead to severe complications such as hepatic encephalopathy and hepatopulmonary syndrome. Traditional surgical interventions pose high risks, making interventional therapies a preferred option due to their minimally invasive nature.

Data Highlights

Key Findings

• The overall success rate of interventional therapy for CPSS was 73%.
• The technical success rate was significantly higher in the intrahepatic portal-systemic shunt group (94.4%) compared to the Abernethy malformation group (25%).
• Only mild complications were observed, with a complication rate of 3.8%.
• Postoperative normalization of liver function parameters was achieved in 63% of successfully treated patients.
• All patients with elevated blood ammonia levels showed improvement post-intervention.

Clinical Implications

Interventional therapy for CPSS in pediatric patients demonstrates a high success rate and low complication profile, suggesting it as a viable first-line treatment option. Clinicians should consider individualized approaches based on anatomical subtype to optimize outcomes.

Conclusion

The study presents data on the safety and efficacy of interventional embolization strategies for children with CPSS.

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3. Pediatric Cardiology, 2024 -- A National Comparison of Interventional and Surgical Strategies for Pulmonary Atresia with Intact Ventricular Septum: Insights from a Comprehensive Literature Review
4. Congenital Portosystemic Shunts – A Review, 2026
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7. Impact of Portal Flow on the Prognosis of Children With Congenital Portosystemic Shunt: A Multicentric Observation Study in Japan - ScienceDirect
8. Portosystemic shunt in children: Outcomes from a pediatric referral center - ScienceDirect