Noninvasive Multifocal Deep Brain Stimulation to Improve Cognitive Function in MCI
Overview
This study investigates the effects of dual-target noninvasive neuromodulation on working memory in patients with mild cognitive impairment (MCI). Using transcranial magnetic stimulation and transcranial temporal interference stimulation, the trial aims to assess cognitive function in this population.
Background
Working memory (WM) is crucial for daily functioning and is often impaired in individuals with mild cognitive impairment (MCI), which can precede dementia. This study explores a dual-target stimulation approach to improve WM in MCI patients.
Data Highlights
No numerical data or trial results were provided in the source material.
Key Findings
The study utilized a quadruple-blind, randomized, placebo-controlled, crossover design.
Participants included patients with amnestic MCI and MCI with Lewy bodies.
Transcranial magnetic stimulation was applied to the left inferior cerebellar hemisphere.
Striatal transcranial temporal interference stimulation was employed as a novel method for brain modulation.
The trial was conducted in accordance with the Declaration of Helsinki and received ethical approval.
Clinical Implications
Understanding the effects of dual-target stimulation could inform future research on cognitive deficits in MCI.
Conclusion
This study presents a novel approach to working memory in MCI patients through noninvasive neuromodulation.
by Umberto Nencha, Monika Pupíková, Margaux di Natale, Pablo Maceira-Elvira, Martin Gajdoš, Elena Beanato, Stavriani Skarvelaki, Rebecca Jones, Isabel Ericson, Martin Lamoš, Andrea Nuti, Fabienne Windel, David Ondráček, Adam Šimo, Ela Vojtková, Klára Špunarová, Vincent Alvarez, Oana Simionescu, Giovanni B. Frisoni, Estelle Raffin, Irena Rektorová, Friedhelm C. Hummel
