Perioperative Adverse Events in Primary Palatoplasty: “Risk Factors and Impact on Care Escalation in a Multicenter Cohort” - Report - MDSpire
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Perioperative Complications Associated with Primary Palatoplasty: Identifying Risk Factors and Their Influence on Increased Healthcare Needs in a Multicenter Study

  • By

  • Febina Padiyath

  • Elizabeth M. O'Brien

  • Jennifer Nam

  • Paula Hu

  • Nishil Mehta

  • Marc Parris

  • Anthony Alexander

  • Ashley Hodges

  • Goretti Chiang

  • Vinícius Caldeira Quintão

  • Ricardo Vieira Carlos

  • Gabriel Soares de Sousa

  • Asif Padiyath

  • Susan C. Nicolson

  • John Fiadjoe

  • Oksana A. Jackson

  • Lisa K. Lee

  • Annery G. Garcia-Marcinkiewicz

  • May 22, 2026

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Clinical Report: Perioperative Complications Associated with Primary Palatoplasty

Overview

This study investigates the incidence of perioperative adverse events in patients undergoing primary palatoplasty and identifies associated risk factors.

Background

Cleft palate is a prevalent congenital condition that necessitates surgical intervention for improved speech and quality of life. Patients undergoing palatoplasty face unique airway challenges during anesthesia, which can increase the risk of perioperative complications.

Data Highlights

No specific numerical data or trial data was provided in the source material.

Key Findings

  • The incidence of perioperative adverse events in patients undergoing palatoplasty was reported at 23%.
  • Serious respiratory events in healthy pediatric surgical patients with normal airway anatomy occur at approximately 0.03%.
  • In patients with difficult airways, the incidence of serious respiratory events is around 20%.
  • Risk factors for perioperative adverse events include age, weight, race, and history of airway anatomic abnormalities.
  • Escalation of care was defined as unplanned ICU admission for patients initially planned for floor level care.

Clinical Implications

Healthcare providers should be aware of the increased risk of perioperative complications in patients undergoing palatoplasty, particularly those with specific risk factors. Enhanced preoperative assessment and careful perioperative management may be necessary to mitigate these risks.

Conclusion

The study underscores the importance of identifying risk factors for perioperative adverse events in palatoplasty, which can inform clinical practices and improve patient safety.

Related Resources & Content

  1. Padiyath et al., Pediatric Anesthesia, 2023 -- Perioperative Adverse Events in Primary Palatoplasty: Risk Factors and Impact on Care Escalation in a Multicenter Cohort
  2. Identifying Risk Factors for Pulmonary Complications Following Colorectal Cancer Surgery: Insights from a Multicenter Study in Japan
  3. BJS (British Journal of Surgery) — Effects of Postoperative Complications on Healthcare Costs and Hospital Stay Duration: A Multicenter Prospective Study
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  6. Critical Elements for the Pediatric Periprocedural Anesthesia Environment: Policy Statement
  7. The Pediatrician’s Role in the Evaluation and Preparation of Pediatric Patients Undergoing Anesthesia
  8. All India Difficult Airway Association 2025... : Indian Journal of Anaesthesia
  9. Timing of Primary Surgery for Cleft Palate | New England Journal of Medicine
  10. Surgical management of cleft lip and palate in young children: An umbrella review - PubMed
  11. Global Increase in Oronasal Fistula Rates Following Cleft Palate Repair: A Systematic Review and Meta-Analysis of Reported Fistula Rates - PubMed
  12. Perioperative Adverse Events in Primary Palatoplasty: “Risk Factors and Impact on Care Escalation in a Multicenter Cohort” - Padiyath - Pediatric Anesthesia - Wiley Online Library
  13. Airway Management in Children Undergoing Cleft Lip or Cleft Palate Surgery: An 8-Year Retrospective Analysis of 274 Cases - PubMed
  14. Impact of perioperative circumstances on postoperative respiratory complications in cleft lip and palate patients undergoing palatoplasty - PubMed
  15. Adverse Events Associated with Airway Management in Pediatric Anesthesia: A Prospective, Multicenter, Observational Japan Pediatric Difficult Airway in Anesthesia (J-PEDIA) Study - PubMed

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