Voice Restoration: Expanding Treatment Options

Advances like autologous platelet-rich plasma (PRP) injections are helping patients with structural disorders of the vocal folds.

By
September 29, 2026
6 min

Keck Medicine of USC

Overview

The USC Voice Center is pioneering innovative treatments for vocal fold disorders, including autologous platelet-rich plasma (PRP) injections and a new decellularized allograft adipose matrix. Recent FDA approval of Papzimeos for recurrent respiratory papillomatosis marks a new treatment option for this condition.

Background

Vocal fold disorders can lead to significant morbidity, affecting communication and quality of life. Traditional treatment options have often been limited, necessitating the exploration of novel therapeutic approaches. The USC Voice Center's multidisciplinary strategy integrates medical, surgical, and behavioral therapies to address complex vocal fold conditions.

Data Highlights

No numerical data provided in the source material.

Key Findings

PRP injections have shown improvements in voice quality for patients with vocal fold scar.
The USC Voice Center is investigating a decellularized allograft adipose matrix for treating vocal fold atrophy and paralysis.
FDA approval of Papzimeos offers a new immunotherapy option for recurrent respiratory papillomatosis.
51.4% of patients requiring multiple surgeries for RRP achieved a complete response after treatment with Papzimeos.
The center's approach combines clinical trials with a focus on regenerative medicine.

Clinical Implications

Clinicians should consider emerging treatments such as PRP and innovative fillers as part of a comprehensive care plan for patients with complex vocal fold conditions.