Global Prevalence and Impact of Pediatric Gut-Brain Interaction Disorders: Findings from the Rome Foundation's International Study

By
Samuel Nurko
Tiffany Taft
Olafur S Palsson
Marc Benninga
Carlo DiLorenzo
Rachel Rosen
Miguel Saps
Johann P Hreinsson
Xiucai Fang
Mizu Jiang
Caterina Strisciuglio
Erick Toro-Monjaraz
Ami D Sperber
October 1, 2026

Overview

This study reveals that pediatric disorders of gut-brain interaction (DGBI) affect nearly one-third of children globally, with variations by disorder and country.

Background

Pediatric DGBI are recognized as contributors to healthcare utilization and impaired quality of life among children. Global evidence on the impact and characteristics of these disorders has been limited. This study provides standardized prevalence estimates and insights into the burden of DGBI.

Data Highlights

No numerical data available in the provided source.

Key Findings

Pediatric DGBI affect almost one-third of children based on Rome V criteria.
Prevalence of DGBI varies significantly by disorder and country.
These disorders contribute to burdens on both children and caregivers.
The study utilized a multinational sample from China, Italy, Mexico, and the USA.
New diagnoses were introduced in the Rome V criteria, enhancing the classification of DGBI.

Clinical Implications

Understanding the prevalence and impact of these disorders can inform management strategies for affected children and their families.

Conclusion

This study provides insights into the global prevalence and impact of pediatric DGBI.

Global Prevalence and Impact of Pediatric Gut-Brain Interaction Disorders: Findings from the Rome Foundation's International Study