Sex-related associations between psychoemotional factors and health-related quality of life in patients with chronic low back pain - Report - MDSpire

Sex-related associations between psychoemotional factors and health-related quality of life in patients with chronic low back pain

  • By

  • Mariia Ovdii

  • Mykola Kondratiuk

  • Lilia Yaremenko

  • Maria Prokopiv

  • Kateryna Potapova

  • Andrii Borysenko

  • Olena Lazarieva

  • Iurii Kuchyn

  • June 30, 2026

  • 0 min

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Gender Differences in the Relationship Between Psychoemotional Factors and HRQoL

Overview

This study evaluates sex-stratified associations between psychoemotional factors and health-related quality of life (HRQoL) in adults with chronic low back pain (CLBP). Findings indicate that psychoemotional factors are associated with HRQoL.

Background

Chronic low back pain (CLBP) is a significant public health issue, affecting a substantial portion of the population and leading to considerable psychosocial burden and economic costs. This study aims to clarify how psychoemotional factors relate to HRQoL across genders.

Data Highlights

FactorWomenMen
Clinically Significant AnxietyNo significant differenceNo significant difference
Clinically Significant DepressionNo significant differenceNo significant difference
High Perceived StressNo significant differenceNo significant difference
KinesiophobiaAssociated with severe pain (OR 9.00, 95% CI 2.01–40.32)No significant association after correction

Key Findings

  • Psychoemotional factors are associated with HRQoL in adults with CLBP.
  • Women showed lower HRQoL scores in vitality, mental health, social functioning, and general health due to elevated psychoemotional burden.
  • Men's associations included a broader range of HRQoL domains, such as physical functioning and role limitations.
  • No significant psychoemotional indicators were associated with severe pain in men after correction for multiple testing.
  • Exploratory analyses did not demonstrate robust interaction effects by sex.

Clinical Implications

The findings highlight the importance of considering psychoemotional factors during the assessment and rehabilitation of patients with CLBP.

Conclusion

This study reveals distinct patterns between genders in the relationship between psychoemotional factors and HRQoL in CLBP.

Related Resources & Content

  1. Pain Medicine, 2023 -- Biobehavioral phenotypes of chronic low back pain: Psychosocial subgroup identification using latent profile analysis
  2. European Radiology, 2023 -- Assessment of Lumbar Paraspinal Muscle Quality in Chronic Low Back Pain Patients: Correlations with Pain Duration, Intensity, and Quality of Life
  3. npj Digital Medicine, 2023 -- Defining and validating a multidimensional digital metric of health states in chronic back and leg pain
  4. WHO, 2023 -- Guidelines for non-surgical management of chronic primary low back pain in adults in primary and community care settings
  5. Clinical Rheumatology — Assessing Quality of Life in Patients with Rheumatic Disorders
  6. Effectiveness of mindfulness meditation on the quality of life, pain intensity, mobility and physical function in adults with chronic low back pain: a systematic review and meta-analysis
  7. Mindfulness vs Cognitive Behavioral Therapy for Chronic Low Back Pain Treated With Opioids: A Randomized Clinical Trial
  8. WHO guideline for non-surgical management of chronic primary low back pain in adults in primary and community care settings
  9. Comparative effects of exercise modalities and dose parameters on chronic low back pain in adults: a systematic review and network meta-analysis
  10. Sex-based differences in biomechanical function for chronic low back pain and how it relates to pain experience | European Spine Journal | Springer Nature Link
  11. Quality of Life in Patients with Chronic Low Back Pain and Differences by Sex: A Longitudinal Study - PubMed
  12. Prevalence of Depression and Anxiety Among Adults With Chronic Pain
  13. Sex differences in health-related quality of life among adults in the US: results from the medical expenditures panel survey data | BMC Public Health | Springer Nature Link

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