Undetected Anal and Anorectal Tumors in Endoscopic Assessments: A Retrospective Analysis Over Ten Years - Report - MDSpire

Undetected Anal and Anorectal Tumors in Endoscopic Assessments: A Retrospective Analysis Over Ten Years

  • By

  • Zhu-Jun Wu

  • Hui Gong

  • Ya-Xin Li

  • Yuan Li

  • Wei-Yi Wu

  • Lin-Jie Guo

  • February 6, 2026

  • 0 min

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Clinical Report: Undetected Anal and Anorectal Tumors in Endoscopic Assessments

Overview

This retrospective analysis reveals that approximately 12% of anal and anorectal tumors are missed during colonoscopy, primarily due to inadequate visualization and low rates of retroflexion examination. Standardizing examination procedures and enhancing endoscopists' knowledge may mitigate these missed diagnoses.

Background

Anal and anorectal tumors, while rare, account for 4% of lower gastrointestinal tract cancers and pose significant diagnostic challenges during endoscopic assessments. Missed diagnoses can lead to delayed treatment and poorer patient outcomes. Understanding the factors contributing to these missed diagnoses is crucial for improving detection rates and patient care.

Data Highlights

No numerical data available.

Key Findings

  • 12% of anal and anorectal tumors were missed during colonoscopy.
  • Inadequate visualization and low retroflexion rates contributed to missed diagnoses.
  • Exposure errors, judgment errors, and biopsy errors were identified as primary causes of missed tumors.
  • Standardizing endoscopic examination procedures may reduce the incidence of missed diagnoses.
  • Endoscopists' familiarity with anal and anorectal tumor features is critical for accurate detection.

Clinical Implications

Healthcare professionals should prioritize thorough endoscopic examinations, including retroflexion, to enhance the detection of anal and anorectal tumors. Continuous education and training for endoscopists on the features of these tumors may further improve diagnostic accuracy.

Conclusion

The findings underscore the importance of improving endoscopic techniques and training to reduce the rate of missed anal and anorectal tumors, ultimately enhancing patient outcomes.

References

  1. Dinis-Ribeiro M, et al., Updates in Surgery, 2025 -- Recognizing the Rare and Dramatic Diagnosis of Anorectal Melanoma: The Importance of Clinical Awareness
  2. Dinis-Ribeiro M, et al., Journal of Gastrointestinal Surgery, 2026 -- Diagnostic accuracy of 1,000 endorectal ultrasounds before transanal endoscopic microsurgery for rectal neoplastic lesions
  3. Dinis-Ribeiro M, et al., Journal of Gastrointestinal Surgery, 2023 -- Endorectal Ultrasound (ERUS): A Precise and Essential Method for Selecting Candidates for Transanal Excision/Transanal Endoscopic Microsurgery (TAE/TEM) in Early Rectal Cancer Stages
  4. Dinis-Ribeiro M, et al., Techniques in Coloproctology, 2023 -- Postoperative Surveillance in Oncology Following Transanal Total Mesorectal Excision for Rectal Tumors
  5. ASGE/ACG, 2024 -- Colonoscopy Quality Standards
  6. NIH, 2024 -- HIV Clinical Guidelines Now Recommend High Resolution Anoscopy as Part of Anal Cancer Screening Program for People with HIV
  7. Dinis-Ribeiro M, et al., BMC Gastroenterology, 2026 -- Clinical value of rectal retroflexion during colonoscopy: a retrospective analysis
  8. https://www.asge.org/docs/default-source/default-document-library/asge-acg-qi-for-colonoscopy-faq_oct24.pdf?sfvrsn=dff3665f_4
  9. HIV Clinical Guidelines Now Recommend High Resolution Anoscopy as Part of Anal Cancer Screening Program for People with HIV | NIH
  10. Clinical value of rectal retroflexion during colonoscopy: a retrospective analysis | BMC Gastroenterology | Springer Nature Link

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