National trends and county-level geographic disparities in mortality from operationally defined cardiovascular–kidney–metabolic stages 4 and 4b in the United States - Report - MDSpire
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National trends and county-level geographic disparities in mortality from operationally defined cardiovascular–kidney–metabolic stages 4 and 4b in the United States
Trends in Mortality and Geographic Variations for Advanced CKM Syndrome
Overview
This report analyzes mortality trends for advanced stages 4 and 4b of cardiovascular–kidney–metabolic syndrome in the U.S. from 1999 to 2023, revealing an overall decline in mortality rates but a concerning rebound in recent years. Geographic disparities in mortality rates highlight the need for targeted interventions.
Background
Advanced cardiovascular–kidney–metabolic (CKM) syndrome represents a critical public health issue due to its association with high morbidity and mortality rates. Understanding mortality trends and geographic variations is essential for developing effective prevention and management strategies. The recent reversal in mortality trends underscores the urgency of addressing these disparities.
Data Highlights
Year
Stage 4 Mortality (per 100,000)
Stage 4b Mortality (per 100,000)
1999
505.54
45.95
2023
353.30
33.98
Key Findings
Age-adjusted mortality for stage 4 declined from 505.54 to 353.30 per 100,000 from 1999 to 2023.
Stage 4b mortality decreased from 45.95 to 33.98 per 100,000 during the same period.
Mortality trends for stage 4 reversed after 2013, showing an annual percent change of +1.17%.
Stage 4b mortality began to increase after 2015, with an annual percent change of +4.63%.
Geographic clustering revealed high-burden areas in the Deep South and Appalachia for stage 4 mortality.
Stage 4b hotspots were more dispersed, indicating varied regional impacts.
Clinical Implications
Healthcare professionals should be aware of the rising mortality trends in advanced CKM syndrome, particularly in specific geographic areas. Targeted interventions and integrated care strategies are necessary to address the disparities and improve outcomes for affected populations.
Conclusion
The findings highlight a concerning rebound in mortality rates for advanced CKM syndrome, emphasizing the need for enhanced surveillance and targeted interventions to mitigate geographic disparities.
