Rare Case report and Literature Review of Peripheral T-Cell Lymphoma Presenting as Massive Gastrointestinal Hemorrhage: An Unusual Etiology Demanding Emergency Surgical Intervention - Report - MDSpire

Rare Case report and Literature Review of Peripheral T-Cell Lymphoma Presenting as Massive Gastrointestinal Hemorrhage: An Unusual Etiology Demanding Emergency Surgical Intervention

  • By

  • Liu, Zhou

  • Zhang, Liang

  • Chen, Qianqian

  • He, Hua hui

  • Peng, Wei

  • Liu, Yanliang

  • Li, Guang

  • Zhan, Ying li

  • April 20, 2026

  • 0 min

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Clinical Report: Uncommon Presentation of Peripheral T-Cell Lymphoma

Overview

This report details a rare case of peripheral T-cell lymphoma (PTCL) presenting as severe gastrointestinal bleeding, initially misdiagnosed as ulcers. The patient required urgent surgical intervention after conservative treatments failed, highlighting the critical need for awareness of PTCL's atypical presentations.

Background

Peripheral T-cell lymphoma is a rare and aggressive form of lymphoma that can present with various symptoms, including gastrointestinal bleeding. Early recognition and intervention are crucial, as misdiagnosis can lead to severe complications, including hemorrhagic shock. Understanding the clinical manifestations of PTCL can improve patient outcomes through timely surgical and oncological management.

Data Highlights

Remove HTML tags; consider adding qualitative data or case specifics if available.

Key Findings

  • The patient presented with recurrent gastrointestinal hemorrhage misidentified as ulcers.
  • Conservative treatments, including corticosteroids, were ineffective in managing the bleeding.
  • An emergency exploratory laparotomy revealed multiple longitudinal ulcers and active bleeding sites.
  • Histopathological analysis confirmed the diagnosis of peripheral T-cell lymphoma.
  • Postoperative management led to significant improvement in gastrointestinal bleeding.

Clinical Implications

Suggest specific diagnostic tests or criteria for PTCL to improve clinical guidance.

Conclusion

Reiterate the importance of differential diagnosis in cases of gastrointestinal bleeding.

Related Resources & Content

  1. Peripheral T‐ and natural killer‐cell lymphomas: ESMO‐EHA Clinical Practice Guideline for diagnosis, treatment, and follow‐up - PMC
  2. Intensive Care Medicine — Uncommon Case of Thoracic Spleen Leading to Acute Gastrointestinal Bleeding from Esophageal Varices
  3. Journal of Gastrointestinal Surgery — Evaluation and Management of Postoperative Abdominal Arterial Hemorrhage Following Radical Gastrectomy: Insights from a Retrospective Study of 1875 Gastric Cancer Resections
  4. Gastric Cancer — Initial Angiographic Alterations Following Hemostatic Radiotherapy for Bleeding in Gastric Cancer: Insights into Mechanisms and Immediate Treatment Outcomes
  5. The New Gastroenterologist — Understanding Lower Gastrointestinal Bleeding: Insights from Two Experts
  6. Peripheral T‐ and natural killer‐cell lymphomas: ESMO‐EHA Clinical Practice Guideline for diagnosis, treatment, and follow‐up - PMC
  7. Brentuximab vedotin plus chemotherapy for the treatment of front-line systemic anaplastic large cell lymphoma: subgroup analysis of the ECHELON-2 study at 5 years’ follow-up | Blood Cancer Journal
  8. Canadian Association of Gastroenterology Clinical Practice Guideline for the Endoscopic Management of Nonvariceal Nonpeptic Ulcer Upper Gastrointestinal Bleeding

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