Levels of vascular endothelial growth factor and filtration surgery outcomes in diabetic patients with acute primary angle closure - Report - MDSpire

Levels of vascular endothelial growth factor and filtration surgery outcomes in diabetic patients with acute primary angle closure

  • By

  • Tianwei Qian

  • Mingshui Fu

  • Hao Zhou

  • Zhihua Zhang

  • Ying Hu

  • July 14, 2026

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Clinical Report: Association of Aqueous Humor VEGF Levels with Surgery Results

Overview

This study investigates the relationship between aqueous humor vascular endothelial growth factor (VEGF) levels and surgical outcomes in diabetic patients with acute primary angle closure (APAC).

Background

Acute primary angle closure (APAC) is a critical ophthalmic emergency that can lead to severe complications if not managed promptly. Understanding the factors influencing surgical outcomes in this population is essential for improving patient care. Vascular endothelial growth factor (VEGF) has been implicated in various ocular conditions, and its role in surgical success for APAC patients warrants further exploration.

Data Highlights

GroupNumber of EyesVEGF LevelSurgical Outcome
Success34LowHigher success rate
Failure12HighLower success rate

Key Findings

  • Aqueous VEGF concentrations were significantly higher in the surgical failure group (P = 0.0018).
  • Univariate analysis showed a significant association between higher VEGF levels and surgical failure (P = 0.021, OR = 9.826).
  • Multivariate analysis confirmed the association of higher VEGF levels with surgical failure (P = 0.030, OR = 8.542).
  • The low-VEGF group had a significantly higher overall success rate compared to the high-VEGF group (P = 0.0276).
  • VEGF levels correlated positively with bleb scores (Spearman's ρ = 0.6840, P < 0.0001).

Clinical Implications

Further research is needed to validate these results in larger cohorts.

Conclusion

Higher aqueous humor VEGF levels are associated with less favorable outcomes in filtration surgery for diabetic patients with APAC.

Related Resources & Content

  1. Author(s)/Org, Source, Year -- Title
  2. New Retinal Physician — Minimizing the Risk of Angle Closure Due to Dilation
  3. Glaucoma Physician — Ocular Blood and Aqueous Flow in Relation to Development of Open-angle Glaucoma Recommendations
  4. Retinal Physician — Postoperative Vitreous Hemorrhages Remain an Issue in Severe Proliferative Diabetic Retinopathy
  5. Ophthalmology Management — Anterior-segment OCT in glaucoma management
  6. Minimizing the Risk of Angle Closure Due to Dilation
  7. Ocular Blood and Aqueous Flow in Relation to Development of Open-angle Glaucoma Recommendations
  8. Postoperative Vitreous Hemorrhages Remain an Issue in Severe Proliferative Diabetic Retinopathy
  9. Primary Angle-Closure Disease Preferred Practice Pattern® - Ophthalmology
  10. Controversies, consensuses, and guidelines for acute primary angle closure attack
  11. World Glaucoma Association » Consensus 12
  12. 24-month prospective randomized comparison of ab externo penetrating canaloplasty versus trabeculectomy in primary angle-closure glaucoma - ScienceDirect
  13. Aqueous humour biomarker profiles in angle-closure glaucoma: systematic review and meta-analysis - PubMed
  14. Trabeculectomy Augmented With Anti-VEGF Improves Surgical Outcomes in Glaucoma: A Systematic Review and Meta-Analysis - PubMed
  15. Expression and clinical significance of IGF-1 and PDGF in aqueous humor and serum of diabetic patients with visually significant cataract

Original Source(s)

Levels of vascular endothelial growth factor and filtration surgery outcomes in diabetic patients with acute primary angle closure

  • by Tianwei Qian, Mingshui Fu, Hao Zhou, Zhihua Zhang, Ying Hu

  • July 14, 2026

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