A systems-oriented Ayurvedic approach in chronic plaque psoriasis with renal inflammatory indicators: a 2-year longitudinal case report - Report - MDSpire

A systems-oriented Ayurvedic approach in chronic plaque psoriasis with renal inflammatory indicators: a 2-year longitudinal case report

  • By

  • Sreelekshmi Mallika

  • Arathy Menon

  • Vishnu Unnikrishnan

  • Preethi Mohan

  • July 6, 2026

  • 0 min

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Clinical Report: A Comprehensive Ayurvedic Strategy for Managing Chronic Plaque Psoriasis

Overview

This case study presents a 22-year-old female with chronic plaque psoriasis and renal inflammation. Significant clinical improvements were observed, including a reduction in PASI scores and urinary inflammatory parameters.

Background

Psoriasis is a chronic systemic inflammatory disorder that can affect multiple systems, including the skin and kidneys. The association between psoriasis and renal abnormalities, along with the impact of psychological stress on disease activity, highlights the need for further exploration of holistic interventions.

Data Highlights

ParameterBaselinePost-Treatment
PASI Score526
Perceived Stress Scale (PSS)3717
Urine Protein-Creatinine Ratio (UPCR)ElevatedImproved

Key Findings

  • A 22-year-old female with chronic plaque psoriasis and renal inflammation showed marked improvement after Ayurvedic treatment.
  • PASI score decreased from 52 to 6 following the first treatment schedule.
  • Perceived Stress Scale scores improved significantly from 37 to 17 after treatment.
  • Urinary inflammatory parameters showed reduction post-treatment.
  • The patient maintained near-complete remission for approximately 2 years.
  • A mild recurrence occurred with a PASI score of 12, which improved to 5 after a second treatment schedule.

Clinical Implications

The findings indicate that Ayurvedic interventions were associated with improvements in chronic plaque psoriasis, particularly in patients with renal inflammation and psychological stress.

Conclusion

This case study illustrates the findings of a comprehensive Ayurvedic strategy in managing chronic plaque psoriasis and its systemic effects.

Related Resources & Content

  1. Frontiers in Immunology, 2026 -- Navigating renal safety in the biologic treatment of psoriasis: from immunologic mechanisms to clinical practice
  2. Clinical Rheumatology, 2026 -- Assessment of Serum TWEAK Levels and Treatment Outcomes in Psoriasis and Psoriatic Arthritis: A Prospective Comparative Study of Adalimumab versus Methotrexate
  3. Frontiers in Immunology, 2026 -- Psoriasis as a systemic inflammatory disease: an immune set-point framework for comorbidities and relapse
  4. S3 Guideline for the treatment of psoriasis vulgaris, adapted from EuroGuiDerm – part 1: Treatment recommendations and monitoring, PMC, 2026
  5. Renal biopsy findings in psoriasis patients with renal involvement: a descriptive clinicopathologic study, BMC Nephrology, 2026
  6. Drugs - Real World Outcomes — Addressing Unmet Personal Needs in Psoriasis Patients with Low Disease Activity Treated with Adalimumab, Etanercept, or Ustekinumab
  7. S3 Guideline for the treatment of psoriasis vulgaris, adapted from EuroGuiDerm – part 1: Treatment recommendations and monitoring - PMC
  8. Renal biopsy findings in psoriasis patients with renal involvement: a descriptive clinicopathologic study | BMC Nephrology | Springer Nature Link

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