“Pericoronary adipose tissue attenuation as a marker of global coronary inflammation rather than lesion-specific risk” - Report - MDSpire

“Pericoronary adipose tissue attenuation as a marker of global coronary inflammation rather than lesion-specific risk”

  • By

  • Ernestas Dvinelis

  • Silvija Sakalauske

  • Guste Cesnaite

  • Medeine Kapacinskaite

  • Radoslavas Stasilo

  • Greta Vrublevska

  • Justinas Bacevicius

  • Algridas Tamosiunas

  • Sigita Glaveckaite

  • June 19, 2026

  • 0 min

Share

Assessment of Pericoronary Adipose Tissue Attenuation as an Indicator

Overview

This study investigates the association between pericoronary adipose tissue (PCAT) attenuation and major adverse cardiovascular events (MACE).

Background

Pericoronary adipose tissue (PCAT) attenuation serves as a non-invasive marker of coronary vascular inflammation, which is crucial in understanding coronary artery disease (CAD) progression. Elevated PCAT attenuation reflects local inflammation around coronary lesions.

Data Highlights

MeasureValuep-value
Lesion-level mean PCAT attenuation (ΔHU)-1.9410.019
Lesion-level maximum PCAT attenuation (ΔHU)-2.8990.003
Patient-level hazard ratio (univariable)1.0460.006
Patient-level hazard ratio (multivariable)1.0140.006
Discriminatory performance (AUC)0.591N/A

Key Findings

  • Higher PCAT attenuation is associated with increased MACE risk at the patient level.
  • Lesion-level PCAT attenuation was higher in patients who experienced MACE.
  • Discriminatory performance of PCAT attenuation for predicting MACE is modest (AUC 0.591).
  • PCAT attenuation reflects global coronary inflammatory burden.

Clinical Implications

PCAT attenuation may be considered in cardiovascular risk assessment.

Conclusion

PCAT attenuation is associated with adverse cardiovascular outcomes at the patient level.

Related Resources & Content

  1. Frontiers in Cardiovascular Medicine, 2026 -- Pericoronary adipose tissue radiomics enhances prediction of major adverse cardiovascular events beyond CCTA-derived functional parameters in coronary atherosclerosis
  2. European Radiology, 2024 -- CT Attenuation of Pericoronary Adipose Tissue is Significantly Influenced by Reconstruction Kernels and Iterative Techniques
  3. European Journal of Preventive Cardiology, 2023 -- Perivascular Inflammation's Role in Coronary Microcirculation and Vasoreactivity: Insights into Angina in Non-Obstructive Coronary Artery Disease
  4. Clinical Research in Cardiology, 2021 -- The Role of Epicardial Adipose Tissue in Acute Myocardial Infarction Patients
  5. 2024 ESC Guidelines for the management of chronic coronary syndromes - PubMed
  6. Perivascular Fat Attenuation Index Stratifies Cardiac Risk Associated With High-Risk Plaques in the CRISP-CT Study | JACC
  7. The pericoronary adipose tissue attenuation in CT strongly depends on kernels and iterative reconstructions - PubMed
  8. 2024 ESC Guidelines for the management of chronic coronary syndromes - PubMed
  9. Perivascular Fat Attenuation Index Stratifies Cardiac Risk Associated With High-Risk Plaques in the CRISP-CT Study | JACC
  10. The pericoronary adipose tissue attenuation in CT strongly depends on kernels and iterative reconstructions - PubMed

Original Source(s)

“Pericoronary adipose tissue attenuation as a marker of global coronary inflammation rather than lesion-specific risk”

  • by Ernestas Dvinelis, Silvija Sakalauske, Guste Cesnaite, Medeine Kapacinskaite, Radoslavas Stasilo, Greta Vrublevska, Justinas Bacevicius, Algridas Tamosiunas, Sigita Glaveckaite

  • June 19, 2026

Related Content

Describing digital nursing work in a remote patient monitoring application: Novel convergent mixed methods secondary analysis of feasibility trial data

Murray law-based quantitative flow ratio versus invasive fractional flow reserve in the left anterior descending coronary artery: impact of hydrostatic pressure correction and clinical implications

Cholesterol, high-density lipoprotein, and glucose index as a cardiometabolic marker associated with heart rate variability and 1-year cardiovascular rehospitalization in chronic coronary syndromes with comorbid anxiety: a retrospective cohort study