GCS May Expand CTRCD Assessment - Report - MDSpire

GCS May Expand CTRCD Assessment

Award-winning ASE abstract highlights GCS when GLS assessment is limited by suboptimal apical windows.

  • By

  • Julia Cipriano, MS, CMPP

  • June 29, 2026

  • 4 min

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Clinical Report: GCS May Expand CTRCD Assessment

Overview

A retrospective study indicates that global circumferential strain (GCS) shows moderate correlation with global longitudinal strain (GLS) in identifying mild cancer therapy-related cardiac dysfunction (CTRCD).

Background

Cancer therapy-related cardiac dysfunction (CTRCD) is a significant concern for patients undergoing cancer treatment, as it can lead to adverse cardiovascular outcomes. Accurate assessment of cardiac function is crucial for timely intervention and management. The study explores the potential of GCS as an alternative to GLS, particularly in cases where GLS assessment is hindered by suboptimal imaging conditions.

Data Highlights

MeasureCTRCD GroupNo CTRCD Group
Mean Baseline LVEF56%58%
Mean GLS−19%−19%
Mean GCS−21%−21%
Mean Relative Change in GCS−19%−5%
Mean Relative Change in GLS−19%−4%

Key Findings

  • GCS and GLS showed moderate correlations in both CTRCD and non-CTRCD groups.
  • 92% concordance in relative reductions of GCS and GLS among patients with CTRCD.
  • 93% concordance in relative reductions of GCS and GLS among patients without CTRCD.
  • No significant differences in baseline LVEF, GLS, or GCS between groups.
  • GCS may be more feasible in patients with challenging acoustic windows.

Clinical Implications

Further prospective studies are needed to establish the clinical utility of GCS and validate cutoff values for routine use.

Conclusion

The study highlights the potential role of GCS in the assessment of CTRCD.

Related Resources & Content

  1. Nathan Lawson, ASE 2026 Scientific Sessions / Journal of the American Society of Echocardiography, 2026 -- GCS May Expand CTRCD Assessment
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  4. Clinical Rheumatology — Characteristics of Patients, Disease Presentation, and Diagnostic Outcomes in Individuals Suspected of Giant Cell Arteritis: A Retrospective Study from a Rapid Assessment Clinic in Israel
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  6. 2022 European Society of Cardiology Cardio-oncology Guidelines in Focus - PMC
  7. Clinical Applications of Strain Echocardiography: A Clinical Consensus Statement
  8. The SUCCOUR Trial: A Cardiovascular Imager's Perspective - American College of Cardiology
  9. Cardioprotection Using Strain-Guided Management of Potentially Cardiotoxic Cancer Therapy: 3-Year Results of the SUCCOUR Trial | JACC: Cardiovascular Imaging
  10. Strain surveillance during chemotherapy to improve cardiovascular outcomes: the SUCCOUR-MRI trial | European Heart Journal | Oxford Academic
  11. Strain surveillance during chemotherapy to improve cardiovascular outcomes: the SUCCOUR-MRI trial - PMC
  12. fcvm20241413827 1..15
  13. Cardiovascular Considerations Before Cancer Therapy: Gaps in Evidence and JACC: CardioOncology Expert Panel Recommendations | JACC: CardioOncology

Original Source(s)

GCS May Expand CTRCD Assessment

  • by Julia Cipriano, MS, CMPP

  • June 29, 2026

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