GCS May Expand CTRCD Assessment

Award-winning ASE abstract highlights GCS when GLS assessment is limited by suboptimal apical windows.

By
Julia Cipriano, MS, CMPP
June 29, 2026
4 min

MDSpire News

Overview

A retrospective study indicates that global circumferential strain (GCS) shows moderate correlation with global longitudinal strain (GLS) in identifying mild cancer therapy-related cardiac dysfunction (CTRCD).

Background

Cancer therapy-related cardiac dysfunction (CTRCD) is a significant concern for patients undergoing cancer treatment, as it can lead to adverse cardiovascular outcomes. Accurate assessment of cardiac function is crucial for timely intervention and management. The study explores the potential of GCS as an alternative to GLS, particularly in cases where GLS assessment is hindered by suboptimal imaging conditions.

Data Highlights

Measure	CTRCD Group	No CTRCD Group
Mean Baseline LVEF	56%	58%
Mean GLS	−19%	−19%
Mean GCS	−21%	−21%
Mean Relative Change in GCS	−19%	−5%
Mean Relative Change in GLS	−19%	−4%

Key Findings

GCS and GLS showed moderate correlations in both CTRCD and non-CTRCD groups.
92% concordance in relative reductions of GCS and GLS among patients with CTRCD.
93% concordance in relative reductions of GCS and GLS among patients without CTRCD.
No significant differences in baseline LVEF, GLS, or GCS between groups.
GCS may be more feasible in patients with challenging acoustic windows.