Prevalence and risk factors of cognitive impairment in patients with coronary heart disease: a systematic review and meta-analysis - Report - MDSpire

Prevalence and risk factors of cognitive impairment in patients with coronary heart disease: a systematic review and meta-analysis

  • By

  • Jie Han

  • Bing Xie

  • Na Zhao

  • May 7, 2026

  • 0 min

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Clinical Report: Cognitive Impairment in Coronary Heart Disease Patients

Overview

Cognitive impairment is prevalent in 36.6% of patients with coronary heart disease (CHD). Significant risk factors include age, history of stroke, smoking, diabetes, depression, and anxiety.

Background

Cognitive impairment is a critical concern in patients with coronary heart disease (CHD), as it can significantly affect their quality of life and self-management capabilities. The increasing prevalence of CHD, projected to rise to 18% by 2030, underscores the need for effective identification and intervention strategies for cognitive decline. Understanding the prevalence and associated risk factors of cognitive impairment in this population is essential for improving patient outcomes.

Data Highlights

MeasureValue
Prevalence of Cognitive Impairment36.6% (95% CI 27.6%–45.7%)

Key Findings

  • The prevalence of cognitive impairment in CHD patients is 36.6%.
  • Age is a significant risk factor with an odds ratio (OR) of 1.10.
  • A history of stroke increases the risk with an OR of 1.99.
  • Smoking is associated with a higher risk (OR: 3.05).
  • Diabetes and negative emotions such as depression (OR: 1.67) and anxiety (OR: 2.03) are also significant risk factors.
  • No significant correlation was found between cognitive impairment and education level, hypertension, systolic blood pressure, or HDL-C.

Clinical Implications

Healthcare professionals should prioritize the identification of high-risk groups for cognitive impairment among CHD patients, particularly the elderly, smokers, and those with a history of stroke or diabetes. Implementing dynamic assessments and targeted interventions can help mitigate the risk of cognitive decline and improve patient management.

Conclusion

Cognitive impairment is a significant concern in patients with coronary heart disease, necessitating early identification and intervention strategies. Addressing the identified risk factors can enhance patient care and outcomes.

Related Resources & Content

  1. Frontiers | Prevalence and Risk Factors of Cognitive Impairment in Patients with Coronary Heart Disease: A Systematic Review and Meta-Analysis
  2. European Journal of Preventive Cardiology — The Impact of Diabetes and Coronary Artery Disease on Dementia Risk
  3. Frontiers in Psychiatry — Cognitive impairment and associated factors in elderly patients with schizophrenia: a retrospective observational study with phenotype analysis
  4. European Radiology — Integrating Computed Tomography Angiography and Coronary Artery Calcium Scoring for Enhanced Diagnosis of Coronary Artery Disease: A Meta-Analysis of Patients with Stable Chest Pain Undergoing Invasive Coronary Angiography
  5. Brain — Combined Influence of Cortical Cerebral Microinfarcts and Brain Atrophy on Cognitive Deterioration
  6. New high blood pressure guideline emphasizes prevention, early treatment to reduce CVD risk | American Heart Association
  7. Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab - PubMed
  8. New high blood pressure guideline emphasizes prevention, early treatment to reduce CVD risk | American Heart Association
  9. Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab - PubMed
  10. Frontiers | Prevalence and Risk Factors of Cognitive Impairment in Patients with Coronary Heart Disease: A Systematic Review and Meta-Analysis

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