Accidental alcohol ingestion triggering severe disulfiram-like reaction in a child receiving cefoperazone-sulbactam: a rare case report - Report - MDSpire
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Accidental alcohol ingestion triggering severe disulfiram-like reaction in a child receiving cefoperazone-sulbactam: a rare case report
Clinical Report: Severe Disulfiram-like Reaction Induced by Accidental Alcohol Consumption
Overview
This report details a severe disulfiram-like reaction in a 4-year-old boy following accidental alcohol consumption while on cefoperazone-sulbactam therapy. The child exhibited symptoms consistent with shock.
Background
Disulfiram-like reactions (DLRs) can be life-threatening and are particularly concerning in pediatric patients receiving certain cephalosporins, such as cefoperazone-sulbactam. While DLRs are documented in adults, pediatric cases are rare.
Data Highlights
No numerical or trial data provided in the article.
Key Findings
A 4-year-old boy developed severe symptoms consistent with shock after consuming alcohol while on cefoperazone-sulbactam.
Symptoms included rash, facial flushing, drowsiness, dyspnea, hypotension, and tachycardia.
Initial diagnosis was anaphylactic shock, later revised to cephalosporin-induced disulfiram-like reaction (CIDLR) after alcohol exposure was disclosed.
The child was treated with drug discontinuation, oxygen, fluids, and dexamethasone, with resolution of symptoms within hours.
Clinical Implications
Clinicians should be vigilant for disulfiram-like reactions in pediatric patients treated with cefoperazone-sulbactam following any alcohol exposure.
Conclusion
This case presents a unique example of severe CIDLR in a child following accidental alcohol ingestion during antibiotic therapy.
