Eosinophil Counts, FeNO May Predict Asthma, COPD Exacerbations - Report - MDSpire

Eosinophil Counts, FeNO May Predict Asthma, COPD Exacerbations

  • By

  • Debbie Bunch

  • June 15, 2026

  • 0 min

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Clinical Report: Baseline Eosinophil Levels and FeNO as Predictors of Exacerbations

Overview

This study investigates the predictive value of baseline eosinophil levels and fractional exhaled nitric oxide (FeNO) in forecasting exacerbations in asthma and COPD patients.

Background

Eosinophilic inflammation is implicated in approximately 20% of COPD cases. Understanding the role of eosinophils and FeNO can aid in the transition towards precision medicine in respiratory diseases.

Data Highlights

No numerical data provided in the source material.

Key Findings

  • Baseline eosinophil levels and FeNO measurements are predictors of exacerbations in asthma and COPD.
  • Approximately 20% of individuals with COPD exhibit eosinophilic inflammation.
  • Elevated eosinophil counts and FeNO levels are linked to exacerbation risk.
  • GOLD 2026 guidelines recommend considering ICS therapy based on eosinophil counts.
  • Type 2 inflammation biomarkers, including eosinophils and FeNO, are recognized in asthma and COPD management.

Clinical Implications

Baseline eosinophil levels and FeNO should be considered in the assessment for exacerbation risk in asthma and COPD patients.

Conclusion

The study highlights the importance of eosinophil levels and FeNO in predicting exacerbations.

Related Resources & Content

  1. Frontiers in Medicine, 2026 -- Resident eosinophils in patients with chronic obstructive pulmonary disease: a pilot study
  2. Frontiers in Immunology, 2026 -- Is blood eosinophilia a treatable trait in chronic obstructive airway diseases?
  3. conexiant, 2026 -- Sex Does Not Modify Asthma Attack Predictors
  4. Global Strategy for Asthma Management and Prevention, 2025 -- Updated 2025
  5. Inflammatory and clinical risk factors for asthma attacks (ORACLE2), 2025 -- a patient-level meta-analysis of control groups of 22 randomised trials
  6. Infection — Eosinophil Levels in Peripheral Blood and Their Relationship with COVID-19 Severity: A Retrospective Analysis
  7. | Global Strategy for Asthma Management and Prevention --- | ---Updated 2025
  8. Inflammatory and clinical risk factors for asthma attacks (ORACLE2): a patient-level meta-analysis of control groups of 22 randomised trials - ScienceDirect
  9. https://goldcopd.org/wp-content/uploads/2025/11/KEY-CHANGES-GOLD-2026-10Nov2025.pdf
  10. Fractional exhaled nitric oxide in acute exacerbations of chronic obstructive pulmonary disease: A meta-analysis with meta-regressions - ScienceDirect

Original Source(s)

Eosinophil Counts, FeNO May Predict Asthma, COPD Exacerbations

  • by Debbie Bunch

  • June 15, 2026

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