Clinical Report: Impact of Pyrroloquinoline Quinone on Serum AMH Levels

Overview

This study evaluated the effects of pyrroloquinoline quinone (PQQ) supplementation on serum anti-Mllerian hormone (AMH) levels in healthy women aged 25–42 years. A total of 50 participants received 20 mg/day of PQQ for 90 ± 10 days. Results indicated no significant changes in AMH levels overall, with subgroup analyses revealing inconsistent findings.

Background

Ovarian function is essential for female fertility, and anti-Mllerian hormone (AMH) serves as a key biomarker for ovarian reserve. Antioxidant supplementation, such as PQQ, has been proposed to support ovarian function, but clinical evidence remains limited and mixed.

Data Highlights

No significant changes in AMH levels were observed (1.561 ± 0.689 vs. 1.439 ± 0.772 ng/mL, p = 0.182). In younger participants, AMH showed a non-significant increase (p = 0.056), while older participants experienced a significant decrease (p = 0.033).

Key Findings

• PQQ supplementation did not significantly alter AMH levels in the overall cohort.
• Younger participants with lower baseline AMH showed a non-significant increase in AMH levels.
• Older participants with lower baseline AMH experienced a significant decrease in AMH levels.
• Overall, d-ROMs showed a non-significant reduction across the cohort.
• Subgroup analyses revealed inconsistent findings.

Clinical Implications

Further research with larger sample sizes and control groups is necessary to clarify the effects of PQQ on ovarian biology.

Conclusion

PQQ supplementation did not result in significant changes in AMH levels, and subgroup analyses yielded inconsistent results.

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