A network meta-analysis of the performance of acupoint stimulation therapy in improving fatigue, neurological function, and activities of daily living in patients with multiple sclerosis - Report - MDSpire

A network meta-analysis of the performance of acupoint stimulation therapy in improving fatigue, neurological function, and activities of daily living in patients with multiple sclerosis

  • By

  • Ruiou Chen

  • Hongyu Li

  • Yuwei Ben

  • Boying Zhang

  • Qiang Tang

  • May 26, 2026

  • 0 min

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Clinical Report: Efficacy of Acupoint Stimulation Therapy in MS Patients

Overview

This systematic review and network meta-analysis evaluated the efficacy of various acupoint stimulation therapies on fatigue, neurological function, and daily living activities in individuals with multiple sclerosis (MS).

Background

Multiple sclerosis (MS) is a chronic autoimmune disease that leads to significant disability and impacts patients' quality of life. Current management strategies primarily focus on disease-modifying treatments and symptomatic care. Complementary therapies, such as acupoint stimulation, are being explored for their potential benefits in alleviating MS symptoms.

Data Highlights

InterventionOutcomeEffect Size
Electroacupuncture + Acupoint InjectionNeurological Function (EDSS)MD = -2.9 (95% CrI: -3.4 to -2.3)
AcupressureFatigue (FSS)SMD = -1.3 (95% CrI: -1.6 to -1.0)
Electroacupuncture + Acupoint InjectionActivities of Daily Living (BI)MD = 18 (95% CrI: 8.8 to 28)

Key Findings

  • Electroacupuncture combined with acupoint injection improved neurological function (EDSS).
  • Acupressure therapy relieved fatigue (FSS).
  • Electroacupuncture combined with acupoint injection improved activities of daily living (BI).
  • The study included 23 RCTs with a total of 1,384 patients.
  • Findings should be interpreted with caution due to methodological limitations and clinical heterogeneity.

Clinical Implications

The results indicate that acupoint stimulation therapies may serve as a complementary approach to standard pharmacotherapy in managing symptoms of MS. Clinicians should consider these therapies as part of a comprehensive treatment plan, while remaining aware of the limitations of the current evidence.

Conclusion

Acupoint stimulation therapy shows potential benefits for MS patients in terms of fatigue, neurological function, and daily living activities. However, further research is needed to establish definitive clinical recommendations.

Related Resources & Content

  1. Frontiers in Neurology, 2026 -- A Network Meta-Analysis of the Performance of Acupoint Stimulation Therapy in Improving Fatigue, Neurological Function, and Activities of Daily Living in Patients with Multiple Sclerosis
  2. NICE guideline NG220, 2026 -- Multiple sclerosis in adults: management
  3. Frontiers in Neurology — Acupuncture therapy for post-stroke spasticity: a systematic review and exploratory network meta-analysis of clinical efficacy and dose–response relationship
  4. Frontiers in Oncology — Effectiveness of acupuncture for cancer-related fatigue: a systematic reviews and meta-analysis
  5. Frontiers in Neurology — Comparative effectiveness of acupuncture and Tuina for cervical vertigo: a systematic review and network meta-analysis of randomized controlled trials
  6. Frontiers in Neurology — A Pilot, Single-Arm Feasibility Study of a Multidimensional Behavioural Intervention for Cognitive Fatigability in Multiple Sclerosis: Mental Energy Boost Program
  7. Multiple sclerosis in adults: management
  8. Frontiers | A Network Meta-Analysis of the Performance of Acupoint Stimulation Therapy in Improving Fatigue, Neurological Function, and Activities of Daily Living in Patients with Multiple Sclerosis
  9. Effect of self-acupressure on fatigue and sleep quality in patients with multiple sclerosis: A randomized controlled trial - PubMed
  10. Comparative efficacy of non-pharmacological interventions on fatigue in people with multiple sclerosis: A systematic review and network meta-analysis - ScienceDirect
  11. Efficacy of pharmacologic treatments for fatigue in multiple sclerosis: A systematic review and meta-analysis - ScienceDirect

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