Clinical Report: Efficacy and Safety of Ketamine in Treating SUDs

Overview

This systematic review and meta-analysis evaluated the efficacy and safety of ketamine for treating substance use disorders (SUDs). The findings indicate that ketamine may improve short-term abstinence rates.

Background

Substance use disorders (SUDs) are a significant global health concern, affecting millions and often leading to high relapse rates. Current treatment options are limited.

Data Highlights

Key Findings

• Fifteen randomized controlled trials (RCTs) with 798 participants were included in the analysis.
• Ketamine was associated with significantly improved abstinence rates at less than one month.
• No significant difference in dropout rates was observed between ketamine and control groups.
• Adverse events did not show significant differences, but the evidence was limited.
• The evidence for long-term efficacy and safety of ketamine in treating SUD remains insufficient.

Clinical Implications

Current treatment guidelines do not recommend ketamine for SUD.

Conclusion

In summary, ketamine shows potential for short-term efficacy in treating SUD.

Related Resources & Content

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9. Treatment of Alcohol Use Disorder - NCBI Bookshelf
10. Ketamine-assisted Mindfulness-Oriented Recovery Enhancement for opioid use disorder: a randomized controlled trial | Nature Mental Health
11. appi.ajp.2021.21030277.pdf
12. Role of ketamine in the treatment of substance use disorders: A systematic review - ScienceDirect