Editorial: Cardiovascular risks in cardiovascular-kidney-metabolic syndrome: mechanisms and therapies - Report - MDSpire

Editorial: Cardiovascular risks in cardiovascular-kidney-metabolic syndrome: mechanisms and therapies

  • By

  • Ruoyu Zhou

  • Bo Zhang

  • Weihao Wang

  • Jiyuan Piao

  • Wanlu Ma

  • May 1, 2026

  • 0 min

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Clinical Report: Understanding Cardiovascular Risks in CKM Syndrome

Overview

Revise to specify how novel biomarkers and therapeutic strategies can be integrated into CKM management.

Background

The CKM syndrome framework, introduced by the American Heart Association in 2023, emphasizes the synergistic relationship between metabolic disorders, kidney disease, and cardiovascular disease. Understanding this interplay is crucial for improving patient outcomes, as the coexistence of these conditions significantly increases the risk of severe complications. Effective management requires a holistic approach that considers the complex interactions among these health issues.

Data Highlights

No specific numerical data or trial results were provided in the source material.

Key Findings

Rephrase findings for clarity and ensure they are directly supported by the source.

Clinical Implications

Clinicians should adopt a comprehensive approach to managing patients with CKM syndrome, utilizing novel biomarkers for risk stratification. Early identification and intervention can mitigate the progression of cardiovascular and renal complications associated with this syndrome.

Conclusion

The CKM syndrome framework offers a valuable perspective for understanding and managing the interplay between cardiovascular, kidney, and metabolic health. Continued research into biomarkers and treatment strategies is essential for improving patient care.

References

  1. American Heart Association, 2023 -- Cardiovascular–kidney–metabolic health framework
  2. European Journal of Preventive Cardiology, 2023 -- Cardiovascular–kidney–metabolic syndrome and mortality
  3. European Journal of Preventive Cardiology, 2023 -- Addressing the Intersection of Diabetes and Cardiovascular Disease Prevention
  4. KDIGO, 2024 -- CKD Guideline
  5. European Journal of Preventive Cardiology — MASLD in the cardiovascular–kidney–metabolic health framework: what does it add to the table?
  6. Basic Research in Cardiology — Inter-organ Communication: Strategies and Targets for Cardioprotection and Neuroprotection - Insights from the 12th Hatter Cardiovascular Institute Workshop
  7. Hub - Cardiovascular Kidney Metabolic Health
  8. Effects of Semaglutide on CKD in Type 2 Diabetes
  9. S U P P L E M E N T TO

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