Folliculosebaceous cystic hamartoma of the vulva and groin: a rare case report - Report - MDSpire
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Cystic Folliculosebaceous Hamartoma in the Vulvar and Groin Regions: An Uncommon Case Study

  • By

  • Xudong Chen

  • Chao Yuan

  • Xinghui Li

  • July 2, 2026

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Clinical Report: Cystic Folliculosebaceous Hamartoma in the Vulvar and Groin Regions

Background

Folliculosebaceous cystic hamartoma (FSCH) is a benign adnexal hamartoma that typically occurs on the head and neck, with genital and groin presentations being uncommon. Accurate diagnosis is crucial as FSCH can be mistaken for other vulvar lesions. Understanding the clinical and histopathological features of FSCH is essential for dermatologists and pathologists.

Data Highlights

No numerical data or trial data is presented in this case report.

Key Findings

  • FSCH is characterized by a cystically dilated follicular infundibular structure and mature sebaceous lobules.
  • The case presented involved a 49-year-old woman with a 20-year history of lesions on the vulva and groin.
  • Initial biopsy showed sebaceous hyperplasia-like changes.
  • No recurrence was observed at the 4-month follow-up after excision.
  • Genital and groin presentations of FSCH can be mistaken for other common lesions.

Clinical Implications

Clinicians should be aware of the potential for FSCH to present in the vulvar and groin regions, as misdiagnosis can occur. Adequate excisional biopsy and clinicopathological correlation are necessary for diagnosis.

Conclusion

This case presents an uncommon genital and groin presentation of FSCH with multifocal, linear/beaded lesions and a long indolent course.

Related Resources & Content

  1. Kimura et al., WHO Classification of Skin Tumours, 2025 -- Folliculosebaceous cystic hamartoma
  2. Frontiers in Reproductive Health — Case Report: Bartholin’s gland leiomyoma masquerading as a bartholin’s cyst: a rare clinical entity and diagnostic challenges
  3. Frontiers in Medicine — Inguinal Dermoid Cyst in Hesselbach's Triangle With Diagnostic and Surgical Decision-Making Challenges: A Case Report
  4. Frontiers in Oncology — Case Report: Clinicopathological features and outcomes of superficial cervicovaginal myofibroblastoma: analysis of two cases and a review of the literature
  5. Frontiers in Medicine — High-frequency ultrasound features of cutaneous hidrocystoma: a case series with imaging-pathology correlation
  6. Case Report: Bartholin’s gland leiomyoma masquerading as a bartholin’s cyst
  7. Inguinal Dermoid Cyst in Hesselbach's Triangle
  8. Clinicopathological features and outcomes of superficial cervicovaginal myofibroblastoma
  9. IARC Publications Website - Skin Tumours
  10. Folliculosebaceous Cystic Hamartoma of the Eyelid: A Case Report - PMC
  11. Approach to the Patient With Vulvar Disease - PubMed

Original Source(s)

Folliculosebaceous cystic hamartoma of the vulva and groin: a rare case report

  • by Xudong Chen, Chao Yuan, Xinghui Li

  • July 2, 2026

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