Evaluation of Parafoveal Retinal Function in Epiretinal Membrane Foveoschisis: A Pilot Study Comparing ERM Phenotypes via MP-3 Microperimetry - Report - MDSpire

Evaluation of Parafoveal Retinal Function in Epiretinal Membrane Foveoschisis: A Pilot Study Comparing ERM Phenotypes via MP-3 Microperimetry

  • By

  • Reio Sekine

  • Tatsuya Jujo

  • Kota Kakehashi

  • Kaito Tomokiyo

  • Naoto Uchiyama

  • Naoto Tokuda

  • Hiroshi Toshida

  • Yasushi Kitaoka

  • March 11, 2026

  • 0 min

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Clinical Report: Evaluation of Parafoveal Retinal Function in ERM Foveoschisis

Overview

This pilot study evaluates parafoveal retinal function in patients with epiretinal membrane (ERM) foveoschisis compared to other ERM phenotypes using microperimetry. Findings indicate distinct functional profiles among ERM phenotypes, highlighting the importance of tailored assessments in clinical practice.

Background

Epiretinal membranes are prevalent age-related macular disorders that can lead to significant visual impairment. Understanding the functional implications of different ERM phenotypes, particularly ERM foveoschisis, is crucial for optimizing surgical outcomes and patient care. The study utilizes advanced imaging techniques to explore these differences, aiming to enhance prognostic stratification and treatment planning.

Data Highlights

GroupNumber of EyesPreoperative BCVAPostoperative BCVA
ERM without EIFL16ValueValue
ERM with EIFL11ValueValue
ERM-F5ValueValue

Key Findings

  • Distinct functional profiles were observed among ERM phenotypes using MP-3 microperimetry.
  • ERM-F demonstrated unique parafoveal retinal sensitivity compared to mild ERM and advanced ERM with EIFL.
  • Preoperative and postoperative BCVA varied significantly across the different ERM phenotypes.
  • Metamorphopsia assessment via M-CHARTS provided additional insights into patient-reported visual distortion.
  • Microperimetry proved to be a sensitive endpoint for evaluating localized retinal function in tractional macular disorders.

Clinical Implications

The findings underscore the necessity for comprehensive functional assessments in patients with ERM, particularly those with foveoschisis. Tailoring surgical interventions based on phenotype-specific characteristics may enhance visual outcomes and patient satisfaction.

Conclusion

This pilot study highlights the importance of differentiating ERM phenotypes to better understand their functional implications. Future research should focus on larger cohorts to validate these findings and refine treatment strategies.

References

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  2. Retinal Physician, 2017 -- NEW PRODUCT APPLICATIONS: Microperimetry’s Bigger Picture
  3. Yong SO, Lam WC, Retinal Physician, 2011 -- Differential Diagnosis of Macular Holes and Pseudoholes
  4. PubMed, 2020 -- Optical coherence tomography-based consensus definition for lamellar macular hole
  5. PubMed, 2023 -- Visual Function in Patients With Idiopathic Epiretinal Membrane Surgery: Evaluated by Microperimetry
  6. Retinal Physician — Multimodal Imaging: Redefining Retinal Disease With Current Technology
  7. Optical coherence tomography-based consensus definition for lamellar macular hole - PubMed
  8. OPH534851 30..43
  9. Visual Function in Patients With Idiopathic Epiretinal Membrane Surgery: Evaluated by Microperimetry - PubMed

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