Sonazoid-enhanced ultrasound for preoperative localization and characterization of sentinel lymph nodes in patients with cutaneous melanoma - Report - MDSpire

Sonazoid-enhanced ultrasound for preoperative localization and characterization of sentinel lymph nodes in patients with cutaneous melanoma

  • By

  • Binbin Jiang

  • Liqi Sun

  • Lu Si

  • Jiayong Liu

  • Chuanliang Cui

  • Kun Yan

  • Shanshan Yin

  • May 25, 2026

  • 0 min

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Ultrasound Enhancement with Sonazoid for Preoperative Identification and Assessment of Sentinel Lymph Nodes in Cutaneous Melanoma Patients

Overview

This study evaluates the feasibility and clinical safety of Sonazoid, a novel ultrasound contrast agent, for sentinel lymph node (SLN) identification in cutaneous melanoma patients.

Background

Cutaneous malignant melanoma is a prevalent skin malignancy, with sentinel lymph nodes being critical for staging and treatment planning. Accurate identification of SLNs is essential, as they are often the first site of melanoma metastases. Traditional localization methods have limitations, prompting the exploration of advanced imaging techniques like contrast-enhanced ultrasound.

Data Highlights

No numerical data or trial results were provided in the source material.

Key Findings

['Sonazoid demonstrates prolonged retention in lymphatic tissue, enhancing SLN visualization.', 'Contrast-enhanced ultrasound (CEUS) with Sonazoid offers advantages over traditional radioactive isotopes and blue dye.', 'Sonazoid is well-tolerated and shows high diagnostic reliability in SLN identification.']

Clinical Implications

The use of Sonazoid in CEUS may provide an alternative for SLN identification in melanoma patients.

Conclusion

Sonazoid-enhanced ultrasound represents an advancement in the preoperative assessment of sentinel lymph nodes in cutaneous melanoma.

Related Resources & Content

  1. Utilizing Hybrid SPECT/CT for Enhanced Lymphatic Mapping in Breast Cancer Patients, Springer, 2008 -- https://link.springer.com/article/10.1007/s00268-008-9618-5
  2. Utilizing Preoperative Contrast-Enhanced Ultrasound and Intra-Lymph Node Methylene Blue Injection for Sentinel Lymph Node Detection: A Minimally Invasive Approach to Sentinel Lymph Node Biopsy, European Radiology, 2025 -- https://link.springer.com/article/10.1007/s00330-025-11932-3
  3. Imaging Improves Detection of cSCC Nodal Spread, Conexiant -- https://conexiant.com/dermatology/articles/imaging-improves-detection-of-cscc-nodal-spread/
  4. Cutaneous melanoma: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up, Frontiers in Endocrinology, 2025 -- https://pmc.ncbi.nlm.nih.gov/articles/PMC7618628/?utm_source=openai
  5. Frontiers in Endocrinology — A multimodal ultrasound-based model combining tumor radiomics and axillary lymph node morphologic classification for predicting axillary nodal burden in breast cancer
  6. Cutaneous melanoma: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up - PMC
  7. Preoperative ultrasound before sentinel lymph node biopsy in melanoma in the era of neoadjuvant treatment: a systematic review and meta-analysis of diagnostic performance and cost analysis - ScienceDirect
  8. Sentinel Lymph Node Characterization with a Dual-Targeted Molecular Ultrasound Contrast Agent - PMC

Original Source(s)

Sonazoid-enhanced ultrasound for preoperative localization and characterization of sentinel lymph nodes in patients with cutaneous melanoma

  • by Binbin Jiang, Liqi Sun, Lu Si, Jiayong Liu, Chuanliang Cui, Kun Yan, Shanshan Yin

  • May 25, 2026

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