Clinical Report: The Systemic Immune-Inflammation Index as a Distinct Predictor of Major Adverse Cardiovascular Events in Individuals with Coronary Artery Ectasia

Overview

This study evaluates the systemic immune-inflammation index (SII) as an independent predictor of major adverse cardiovascular events (MACE) in patients with coronary artery ectasia (CAE). Findings indicate that elevated SII levels correlate with increased risk of MACE.

Background

Coronary artery ectasia (CAE) is a condition characterized by the dilation of coronary arteries, which can lead to significant cardiovascular events despite the absence of obstructive coronary disease. The systemic immune-inflammation index (SII) may provide insights into the inflammatory status and risk of adverse events in this population.

Data Highlights

Key Findings

• 18% of patients with CAE experienced major adverse cardiovascular events (MACE) during follow-up.
• Baseline SII levels were significantly higher in patients who developed MACE.
• ROC analysis showed SII had good discriminatory ability for predicting MACE (AUC 0.81).
• Kaplan–Meier analysis indicated lower event-free survival in patients with high SII levels.
• Multivariate Cox regression confirmed SII as an independent predictor of MACE.
• Incorporating SII into clinical models improved prognostic accuracy significantly.

Clinical Implications

The systemic immune-inflammation index (SII) may serve as a valuable biomarker for risk stratification in patients with coronary artery ectasia.

Conclusion

Elevated SII is an independent predictor of MACE in patients with CAE, enhancing the accuracy of risk assessments.

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