Reference values and Z-scores for left ventricular global longitudinal strain in healthy Colombian children: an echocardiographic study - Report - MDSpire

Reference values and Z-scores for left ventricular global longitudinal strain in healthy Colombian children: an echocardiographic study

  • By

  • Yudisay Molina-Mora

  • Andrés Felipe Rubio-Duarte

  • Yuli Salcedo-Oyola

  • Alicia Rincón-Rangel

  • Claudia C. Colmenares-Mejía

  • Valeria Ramirez-Jaramillo

  • Claudia Ximena Flórez-Rodríguez

  • June 5, 2026

  • 0 min

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Clinical Report: Establishing Reference Values for Left Ventricular GLS in Children

Overview

This study establishes reference values and Z-scores for left ventricular global longitudinal strain (GLS) in healthy Colombian children. Significant age-related variations in GLS were observed, emphasizing the need for population-specific reference values.

Background

Left ventricular global longitudinal strain (GLS) is a critical echocardiographic measure for assessing myocardial function, particularly in detecting early dysfunction. Existing reference values are primarily derived from non-Latin American populations, which may not accurately reflect the demographic variability in Latin America. Establishing region-specific reference values is essential for accurate clinical assessment and management of pediatric patients.

Data Highlights

{'2-6': 'Specify z-score range.', '7-12': 'Specify z-score range.', '13-17': 'Specify z-score range.'}

Key Findings

{'weak correlation': 'Add context on clinical implications.'}

Clinical Implications

{'examples': 'Include specific scenarios where reference values improve diagnosis.'}

Conclusion

{'clinical relevance': 'Highlight how these findings can change clinical practice.'}

Related Resources & Content

  1. Pediatric Cardiology, 2018 -- Ethnic Differences in Echocardiographic Normal Values for Left Heart Dimensions in Pediatric Populations: A Comprehensive Review
  2. Clinical Research in Cardiology, 2023 -- Reference Values for Right Ventricular Free Wall and Four-Chamber Longitudinal Strain by Speckle-Tracking Echocardiography Based on Age and Sex: Insights from the Copenhagen City Heart Study
  3. Pediatric Cardiology, 2017 -- Longitudinal Myocardial Strain Fails to Predict Ejection Fraction in Children with Total Cavopulmonary Connection as Evaluated by Cardiac MRI
  4. Clinical Research in Cardiology, 2010 -- Evaluation of Left Ventricular Diastolic Function in Pediatric Patients Following Successful Aortic Coarctation Repair
  5. Clinical Applications of Strain Echocardiography, 2025 -- A Clinical Consensus Statement From the American Society of Echocardiography
  6. JACC: Advances, 2025 -- Enhancing Prediction of Cancer Therapy-Related Cardiomyopathy From Surveillance Echocardiograms
  7. Clinical Applications of Strain Echocardiography
  8. Enhancing Prediction of Cancer Therapy-Related Cardiomyopathy From Surveillance Echocardiograms: A Children’s Oncology Group Study | JACC: Advances

Original Source(s)

Reference values and Z-scores for left ventricular global longitudinal strain in healthy Colombian children: an echocardiographic study

  • by Yudisay Molina-Mora, Andrés Felipe Rubio-Duarte, Yuli Salcedo-Oyola, Alicia Rincón-Rangel, Claudia C. Colmenares-Mejía, Valeria Ramirez-Jaramillo, Claudia Ximena Flórez-Rodríguez

  • June 5, 2026

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