Efficacy of limaprost combined with unilateral biportal endoscopic surgery in the treatment of lumbar spinal stenosis: based on time effects and stratified analysis - Report - MDSpire
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Efficacy of limaprost combined with unilateral biportal endoscopic surgery in the treatment of lumbar spinal stenosis: based on time effects and stratified analysis
Effectiveness of Limaprost in Conjunction with Unilateral Biportal Endoscopic Surgery for Lumbar Spinal Stenosis
Overview
This study evaluates the effectiveness of limaprost combined with unilateral biportal endoscopic (UBE) surgery for lumbar spinal stenosis (LSS). Results indicate improvements in pain relief and neurological function recovery in patients receiving the combined treatment compared to those undergoing UBE surgery alone.
Background
Lumbar spinal stenosis (LSS) is a prevalent degenerative condition, particularly in the elderly, leading to significant pain and functional impairment. Surgical intervention, particularly UBE, has emerged as a minimally invasive option for decompression. However, optimizing postoperative outcomes remains critical, as some patients experience residual symptoms despite surgical intervention.
Data Highlights
Outcome Measure
Intervention Group
Control Group
VAS
Significantly improved
No significant improvement
ODI
Significantly improved
No significant improvement
JOA Score
Significantly improved
No significant improvement
MMT
Significantly improved
No significant improvement
Modified MacNab
Significantly improved
No significant improvement
CSA
No significant improvement
No significant improvement
Anteroposterior Diameter
No significant improvement
No significant improvement
Key Findings
The intervention group showed significantly better VAS scores compared to the control group.
Significant improvements were observed in ODI, JOA, MMT, and modified MacNab scores in the intervention group.
No significant changes were noted in CSA or the anteroposterior diameter of the spinal canal in either group.
Stronger pain relief was noted at 1 month postoperatively in the intervention group.
Neurological function recovery was more pronounced at 3 months postoperatively in the intervention group.
Patients aged ≥65 years, with BMI < 25, and with central-type stenosis were identified as more suitable for the combined treatment.
Clinical Implications
The findings indicate that combining limaprost with UBE surgery may enhance postoperative outcomes in LSS patients, particularly in terms of pain management and neurological recovery.
Conclusion
The study indicates that the combination of limaprost and UBE surgery can lead to improved clinical outcomes for patients with LSS, particularly in pain reduction and neurological recovery.
