Transcriptomic profiling and IgM and IgT repertoire dynamics in rainbow trout gills following primary and secondary challenge with Lactococcus petauri - Report - MDSpire
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Transcriptomic profiling and IgM and IgT repertoire dynamics in rainbow trout gills following primary and secondary challenge with Lactococcus petauri
Clinical Report: Transcriptomic Analysis of IgM and IgT in Rainbow Trout Gills
Overview
This study investigates the immune response of rainbow trout gills to Lactococcus petauri. Re-infected fish exhibited significant clonal expansion of IgM and IgT.
Background
Understanding the immune responses in fish, particularly in mucosal tissues like gills, is crucial for managing aquatic health and disease prevention. The gill-associated lymphoid tissue (GIALT) plays a significant role in the adaptive immune response.
Data Highlights
No numerical data or trial data available.
Key Findings
Memory responses in rainbow trout gills are observed.
Re-infected fish did not up-regulate inflammation-related genes.
Significant clonal expansion of IgM and IgT was observed in re-infected fish.
Increased levels of specific IgM were produced both locally and in serum.
No clonal selection was apparent in the IgM and IgT responses.
Clinical Implications
Understanding these mechanisms could enhance vaccine development and disease prevention in aquaculture.
Conclusion
This research highlights the gills' role in adaptive immune responses during secondary infections.
by Aitor Arrogante, Esther Morel, Beatriz Abós, Samuel Vicente-Gil, Pablo Jiménez-Barrios, Patricia Díaz-Rosales, Pedro Perdiguero, J. Germán Herranz-Jusdado, Carolina Tafalla
