Clinical Report: Associations of Lipoprotein (a) and Apolipoprotein B Levels
Overview
This study evaluates the clinical and biochemical correlates of Lipoprotein(a) and Apolipoprotein B in patients with dyslipidemia and cardiovascular disease. Findings indicate significant correlations between ApoB levels and traditional lipid measures, while Lp(a) variability is influenced by hepatic and renal function markers.
Background
Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of morbidity and mortality, with residual cardiovascular risk persisting despite lipid-lowering therapies. Lipoprotein(a) [Lp(a)] and apolipoprotein B (ApoB) are emerging as independent biomarkers that may enhance cardiovascular risk assessment beyond conventional lipid measures.
Data Highlights
Parameter
Mean ± SD
Lp(a) concentration
30.14 ± 31.50 mg/dL
ApoB concentration
119.87 ± 36.01 mg/dL
Key Findings
The study included 153 adults with a mean age of 57.9 years, predominantly with dyslipidemia (79.1%) and established cardiovascular disease (75.2%).
ApoB levels correlated significantly with total cholesterol (r = 0.49, p < 0.001), triglycerides (r = 0.46, p < 0.001), and LDL-C (r = 0.26, p < 0.01).
Decision tree analysis identified GGT, creatinine, and uric acid as factors influencing Lp(a) variability.
Elevated Lp(a) levels contribute to atherogenesis through proatherogenic and prothrombotic mechanisms.
Clinical Implications
Integrating Lp(a) and ApoB assessment into cardiovascular risk profiling may enhance the identification of residual risk in dyslipidemic populations. This could guide more personalized therapeutic strategies for patients at risk of cardiovascular events.
Conclusion
The study highlights the importance of Lp(a) and ApoB as significant biomarkers in assessing cardiovascular risk.
by Luana Alexandrescu, Daria Maria Alexandrescu, Ionut Tiberiu Tofolean, Doina Ecaterina Tofolean, Steliana Pindichi, Eugen Dumitru, Bogdan Campineanu, Cristina Aftenie, Andreea Nelson Twakor, Alexandra Herlo, Elena Rusu, Diana Raluca Baicu, Madalina Ilie, Filip-Vasile Berariu, Laura Maria Condur
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