Clinical Report: SAPHO Syndrome with Membranous Nephropathy and Kidney Injury
Overview
This report details a case of a 43-year-old male with SAPHO syndrome presenting with renal involvement, specifically stage II membranous nephropathy and analgesic-induced kidney injury. Following treatment, the patient showed significant improvement in symptoms and renal function at one-year follow-up.
Background
SAPHO syndrome is a rare autoimmune disorder characterized by skin and osteoarticular manifestations, often leading to chronic pain and impaired quality of life. Renal involvement in SAPHO syndrome is uncommon, with only a few reported cases of kidney injury. Understanding the potential renal complications is crucial for timely diagnosis and management.
Data Highlights
Parameter
Value
24-hour urine protein
0.51 g/24 h
Serum creatinine
Elevated
Interleukin-1β
4.00 pg/mL
Interleukin-2 receptor
783.86 U/mL
Interleukin-6
68.15 pg/mL
Interleukin-8
67.43 pg/mL
TNF-α
1.32 pg/mL
Key Findings
The patient presented with palmoplantar pustulosis and joint pain, indicative of SAPHO syndrome.
Renal biopsy confirmed stage II membranous nephropathy and analgesic nephropathy.
Initial symptoms included proteinuria and microscopic hematuria, which progressed to significant renal impairment.
After treatment, the patient achieved nearly complete remission of proteinuria and stable renal function at one-year follow-up.
Excessive use of analgesics contributed to the development of kidney injury in this case.
Clinical Implications
Clinicians should be aware of the potential renal complications associated with SAPHO syndrome and consider routine screening for kidney function in affected patients. Early recognition and management of renal involvement can lead to improved outcomes.
Conclusion
This case underscores the importance of monitoring renal function in patients with SAPHO syndrome, particularly those with significant analgesic use. Effective management can lead to substantial recovery of renal function and overall health.
