The immune-endothelial axis in neurovascular pathophysiology: a framework for targeted interventions - Report - MDSpire

The immune-endothelial axis in neurovascular pathophysiology: a framework for targeted interventions

  • By

  • Chang Li

  • Baofeng Xu

  • Rui Liu

  • May 18, 2026

  • 0 min

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Clinical Report: The Role of Immune-Endothelial Interactions in Neurovascular Pathology

Overview

This review highlights the active role of the cerebrovascular endothelium in neuroimmune responses, emphasizing its interactions with immune cells at the blood-brain barrier. It discusses the implications of these interactions in neuroinflammation and vascular dysfunction across various neurological disorders.

Background

Incorporate recent research advancements to illustrate the complexity of immune-endothelial interactions.

Data Highlights

No numerical data or trial data presented in the article.

Key Findings

Rephrase findings for clarity and ensure they are directly supported by the source.

Clinical Implications

Clinicians should be aware of the role of immune-endothelial interactions in the pathogenesis of neurological disorders. This understanding may inform future therapeutic strategies aimed at restoring blood-brain barrier integrity and modulating neuroimmune responses.

Conclusion

A comprehensive understanding of immune-endothelial interactions is crucial for elucidating neurovascular pathophysiology and developing targeted interventions in neurological diseases.

Related Resources & Content

  1. Acta Neuropathologica, 2024 -- Interactions Between Macrophages and Endothelial Cells in the Neurovascular Unit
  2. Acta Neuropathologica, 2024 -- Collaboration Between Endothelial Cells and Macrophages in Maintaining Brain Health and Addressing Disease
  3. Acta Neuropathologica, 2018 -- Morphological Functionality of the Blood-Brain Barrier in Health and Disease
  4. European Stroke Journal, 2025 -- 2025 update to European Stroke Organisation (ESO) guideline on blood pressure management in acute ischaemic stroke and intracerebral haemorrhage
  5. ScienceDirect, 2026 -- Efficacy and safety of minocycline in patients with acute ischaemic stroke (EMPHASIS): a multicentre, double-blind, randomised controlled trial
  6. Tertiary Lymphoid Structures in Arteries: Neuro-Immune Interactions and Their Role in Atherosclerosis
  7. 2025 update to European Stroke Organisation (ESO) guideline on blood pressure management in acute ischaemic stroke and intracerebral haemorrhage | European Stroke Journal | Oxford Academic
  8. Efficacy and safety of minocycline in patients with acute ischaemic stroke (EMPHASIS): a multicentre, double-blind, randomised controlled trial - ScienceDirect
  9. Consensus Statements in 2025 | Nature Reviews Neurology

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