Perioperative Depression and Anxiety Care in Older Patients: A Randomized Clinical Trial - Report - MDSpire
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Management of Depression and Anxiety in Older Surgical Patients: Results from a Randomized Clinical Trial

  • By

  • Joanna Abraham

  • Katherine J. Holzer

  • Simon Haroutounian

  • Bethany Pennington

  • Ana Baumann

  • Ryan Calfee

  • Theresa Cordner

  • Kenneth E. Freedland

  • Thomas Kannampallil

  • Benjamin Kozower

  • Emily Lenard

  • J Philip Miller

  • Mary Politi

  • Michael Yingling

  • Michael S. Avidan

  • Eric J. Lenze

  • September 9, 2026

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Management of Depression and Anxiety in Older Surgical Patients: Results from a Randomized Clinical Trial

Background

Depression and anxiety are prevalent among older adults undergoing surgery, with significant implications for postoperative outcomes. These mental health symptoms are associated with increased risks of complications such as delirium and delayed recovery. Current perioperative care models often inadequately address the mental health needs of this population, highlighting the importance of targeted interventions. Preoperative depression and anxiety symptoms are prevalent, estimated at 10% to 33% for depression and 22% for anxiety in the U.S.

Data Highlights

No numerical data is provided in the source material.

Key Findings

  • Preoperative depression and anxiety symptoms are prevalent in older surgical patients, with estimates ranging from 10% to 33% for depression and 22% for anxiety in the U.S.
  • The intervention developed integrated psychological management and pharmacologic optimization to address mental health needs.
  • Eligibility for the trials required participants to be at least 60 years old with clinically meaningful anxiety and/or depression symptoms.
  • Participants were screened using the Patient Health Questionnaire 4 (PHQ-4) and the PHQ-ADS scale for comprehensive assessment.
  • The study employed a hybrid type 1 effectiveness-implementation design to evaluate both the effectiveness and implementation potential of the intervention.

Clinical Implications

The findings suggest that addressing mental health in older surgical patients through structured interventions may improve postoperative outcomes. Clinicians should consider integrating psychological management and medication optimization in perioperative care for this demographic.

Conclusion

The study underscores the need for effective interventions targeting depression and anxiety in older surgical patients, which may enhance recovery and reduce complications.

Related Resources & Content

  1. The ASCO Post, Clinical Trials Actively Recruiting Geriatric Oncology Patients, 2017 -- Clinical Trials Actively Recruiting Geriatric Oncology Patients
  2. Journal of Surgical Oncology, An Interactive Preoperative Virtual Reality Intervention for Breast Cancer Patients Undergoing Oncological Surgery: A Feasibility and Pilot Randomized Clinical Trial, 2023 -- An Interactive Preoperative Virtual Reality Intervention for Breast Cancer Patients Undergoing Oncological Surgery: A Feasibility and Pilot Randomized Clinical Trial
  3. Frontiers in Psychiatry, Comparative effectiveness of non-pharmacological interventions on depression and anxiety in aging populations: a systematic review and network meta-analysis of randomized controlled trials, 2026 -- Comparative effectiveness of non-pharmacological interventions on depression and anxiety in aging populations: a systematic review and network meta-analysis of randomized controlled trials
  4. Perioperative Depression and Anxiety Care in Older Patients: A Randomized Clinical Trial | Surgery | JAMA Network Open | JAMA Network, 2023 -- Perioperative Depression and Anxiety Care in Older Patients: A Randomized Clinical Trial
  5. Frontiers in Surgery — Trimodal prehabilitation and psychological outcomes in colorectal cancer surgery: preliminary findings from a single-center randomized trial
  6. Perioperative Depression and Anxiety Care in Older Patients: A Randomized Clinical Trial | Surgery | JAMA Network Open | JAMA Network
  7. Preoperative anxiety and its impact on surgical outcomes: A systematic review and meta-analysis - PubMed

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