The cardiovascular risk marker itaconate is sex-dependently associated with legume intake and immune-inflammatory competence in subjects with high BMI - Report - MDSpire
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The cardiovascular risk marker itaconate is sex-dependently associated with legume intake and immune-inflammatory competence in subjects with high BMI
Sex-Specific Associations of Itaconate with Legume Consumption and Inflammation
Overview
This study investigates the relationship between circulating itaconate levels, legume consumption, and immune-inflammatory markers in individuals with elevated BMI.
Background
Cardiovascular disease is a leading cause of morbidity and mortality, influenced by chronic inflammation and immune responses. Itaconate, produced by activated macrophages, is emerging as a key immunometabolic mediator linked to cardiovascular risk.
Data Highlights
No significant differences in circulating itaconate concentrations were observed across categories of legume intake or adherence to the Mediterranean diet.
Key Findings
Circulating itaconate levels did not differ based on legume consumption.
Higher legume intake correlated with a healthier lifestyle profile and lower adiposity.
Monocyte counts were independently associated with circulating itaconate levels.
IL-6 showed a borderline inverse association with itaconate levels (p = 0.053).
A significant interaction between itaconate and sex was found for monocyte counts (p = 0.025).
Clinical Implications
Circulating itaconate may serve as a marker of innate immune activation rather than dietary exposure.
by Amanda Cuevas-Sierra, Andrea Higuera-Gómez, Begoña de Cuevillas, Gabriela Paula-Buestan, María Martínez-Urbistondo, Raquel Castejón, J. Antonio Vargas, José Moisés Laparra, J. Alfredo Martínez
