Mesh-free prepectoral breast reconstruction: a safe and effective alternative - Report - MDSpire

Mesh-free prepectoral breast reconstruction: a safe and effective alternative

  • By

  • Jun Zhang

  • Hai-Kuo Yu

  • Zi-Fan Liu

  • Ran An

  • Zhi-Hao Yu

  • Li Zhang

  • May 20, 2026

  • 0 min

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Clinical Report: Mesh-less prepectoral breast reconstruction: a reliable and efficient option

Overview

This study evaluates the clinical outcomes of mesh-free versus mesh-assisted prepectoral breast reconstruction in breast cancer patients. Findings indicate that mesh-free reconstruction offers significant advantages in terms of operation time and cost without compromising safety or aesthetic satisfaction.

Background

Breast cancer remains the most common malignant tumor among women, necessitating effective reconstruction options post-mastectomy. Prepectoral breast reconstruction has emerged as a preferred method due to its benefits, including reduced postoperative pain and improved aesthetic outcomes. However, reliance on mesh in these procedures raises concerns about complications and costs, making the exploration of mesh-free techniques clinically relevant.

Data Highlights

OutcomeMesh-Free GroupMesh Groupp-value
Operation Time (minutes)107.50125.00<0.001
Hospitalization Cost (RMB)42,242.3660,083.01<0.001
Infection Rate3.13%5.08%0.527
Severe Capsular Contracture Rate2.34%4.24%0.486
Wound Dehiscence Rate2.34%3.39%0.713
Implant Loss Rate2.34%3.39%0.713

Key Findings

  • No significant differences in major complications between mesh-free and mesh groups.
  • Operation time was significantly shorter in the mesh-free group (107.50 vs. 125.00 minutes, p<0.001).
  • Hospitalization costs were lower for the mesh-free group (42,242.36 RMB vs. 60,083.01 RMB, p<0.001).
  • Higher scores in Physical well-being: chest for the mesh-free group (31 vs. 27, p=0.005).
  • In the subgroup analysis, the incidence of severe capsular contracture was higher in the mesh group (20% vs. 7.7%, p=0.193).

Clinical Implications

The findings suggest that mesh-free prepectoral breast reconstruction is a viable option that may reduce operative time and costs while maintaining safety. Clinicians should consider this approach for selected patients, particularly those concerned about the complications associated with mesh.

Conclusion

Mesh-free prepectoral breast reconstruction presents a safe and cost-effective alternative to traditional mesh-assisted techniques, offering comparable outcomes in patient satisfaction and complication rates.

Related Resources & Content

  1. Updates in Surgery, 2025 -- Retrospective Study of 91 Consecutive Cases of Direct-to-Implant Breast Reconstruction
  2. Surgical Endoscopy, 2023 -- Single-incision nipple-sparing subcutaneous mastectomy with immediate implant-based breast reconstruction for the treatment of breast cancer
  3. BJS (British Journal of Surgery), 2023 -- Patient-Reported Outcomes at 3 and 18 Months Following Mastectomy and Immediate Prepectoral Implant-Based Breast Reconstruction: Findings from the UK Pre-BRA Multicenter Cohort Study
  4. Updates in Surgery, 2022 -- Comparison of One-Stage Versus Two-Stage Reconstruction Following Mastectomy in Breast Cancer: Evaluation of Early Outcomes and Patient Satisfaction
  5. Guidance and consensus on prepectoral implant-based breast reconstruction
  6. Prepectoral versus subpectoral implant-based breast reconstruction after skin-sparing mastectomy or nipple-sparing mastectomy (OPBC-02/ PREPEC): a pragmatic, multicentre, randomised, superiority trial
  7. Prepectoral breast reconstruction with and without acellular dermal matrix: a systematic review and meta-analysis
  8. manuscript.pdf
  9. Prepectoral versus subpectoral implant-based breast reconstruction after skin-sparing mastectomy or nipple-sparing mastectomy (OPBC-02/ PREPEC): a pragmatic, multicentre, randomised, superiority trial - PubMed
  10. Prepectoral breast reconstruction with and without acellular dermal matrix: a systematic review and meta-analysis - PubMed

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