Concurrent B-cell acute lymphoblastic leukemia and plasma cell neoplasm with plasmablastic features supporting divergent evolution from a shared precursor: a case report - Report - MDSpire

Concurrent B-cell acute lymphoblastic leukemia and plasma cell neoplasm with plasmablastic features supporting divergent evolution from a shared precursor: a case report

  • By

  • Antonija Babić

  • Ivana Franić Šimić

  • Josip Knežević

  • Koraljka Gjadrov Kuveždić

  • Ivana Ilić

  • Ida Ivek

  • Lara Divjak

  • Alojzija Brčić

  • Klara Bardač

  • Dora Višnjić

  • Radovan Vrhovac

  • Vilma Dembitz

  • Drago Batinić

  • Hrvoje Lalić

  • July 10, 2026

  • 0 min

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Clinical Report: Simultaneous Presence of B-cell Acute Lymphoblastic Leukemia and Plasma Cell Neoplasm

Background

B-cell malignancies are a diverse group of neoplasms, and the co-occurrence of distinct B-cell entities is rare. This case adds to the limited literature on simultaneous B-ALL and PCN presentations.

Data Highlights

No numerical or trial data is available in the source material.

Key Findings

  • A 76-year-old man was diagnosed with both B-ALL and PCN.
  • Initial therapy for B-ALL induced remission of both malignancies.
  • Subsequent relapse showed expansion of a plasmablastic/plasma cell population consistent with PCN.
  • Genomic analysis indicated two clonally related but distinct malignancies.

Clinical Implications

This case emphasizes the need for integrated genomic and immunophenotypic analysis in B-cell malignancies.

Conclusion

The simultaneous occurrence of B-ALL and PCN in this case supports a model of clonal divergence from a shared precursor.

Related Resources & Content

  1. Frontiers | Concurrent B-Cell Acute Lymphoblastic Leukemia and Plasma Cell Neoplasm with Plasmablastic Features Supporting Divergent Evolution from a Shared Precursor: a case report
  2. Blood Cancer Journal — Multi-Omics Analysis of Three Hematological Cancers in a Patient Identifies Their Origin from Clonal Hematopoietic Stem Cells
  3. Frontiers in Oncology — Coexistence of lymphoplasmacytic lymphoma and multiple myeloma: a case report and review of literature
  4. Blood Cancer Journal — Transformation of B-ALL with t(4;11)(q21;q23) KMT2A/AFF1 into Aggressive AML Induced by Blinatumomab: A Comprehensive Analysis of Phenotypic, Cytogenetic, and Molecular Changes Before and After the Switch
  5. Blood Cancer Journal — Exploration of Pluripotency Features in MYC-Driven B-Cell Lymphomas Originating from Germinal Centers
  6. ASH Publishes Guidelines on Management of ALL in AYAs - Hematology.org
  7. EHA–EMN Evidence-Based Guidelines for diagnosis, treatment and follow-up of patients with multiple myeloma | Nature Reviews Clinical Oncology
  8. Frontiers | Concurrent B-Cell Acute Lymphoblastic Leukemia and Plasma Cell Neoplasm with Plasmablastic Features Supporting Divergent Evolution from a Shared Precursor: a case report

Original Source(s)

Concurrent B-cell acute lymphoblastic leukemia and plasma cell neoplasm with plasmablastic features supporting divergent evolution from a shared precursor: a case report

  • by Antonija Babić, Ivana Franić Šimić, Josip Knežević, Koraljka Gjadrov Kuveždić, Ivana Ilić, Ida Ivek, Lara Divjak, Alojzija Brčić, Klara Bardač, Dora Višnjić, Radovan Vrhovac, Vilma Dembitz, Drago Batinić, Hrvoje Lalić

  • July 10, 2026

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