Vitamin D deficiency and metabolic disorders increase albuminuria risk in type 2 diabetes (ACR 0.1–300 mg/g): a nomogram-based stratification - Report - MDSpire
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Vitamin D deficiency and metabolic disorders increase albuminuria risk in type 2 diabetes (ACR 0.1–300 mg/g): a nomogram-based stratification
Clinical Report: Impact of Vitamin D Insufficiency and Metabolic Conditions on Albuminuria Risk
Overview
This study examines the prevalence of vitamin D deficiency in type 2 diabetes patients and its synergistic effect with metabolic disorders on albuminuria risk.
Background
Type 2 diabetes mellitus (T2DM) is a significant global health issue, with diabetic kidney disease (DKD) being a leading cause of end-stage renal disease. Monitoring albuminuria is crucial for assessing renal damage in T2DM patients. Vitamin D deficiency is prevalent in this population.
Data Highlights
Parameter
Value
Prevalence of Vitamin D Deficiency
83.0%
Prevalence in Albuminuria Group
91.8%
Prevalence in Moderate Albuminuria
96.8%
C-index (Training Set)
0.882
C-index (Validation Set)
0.858
Key Findings
83.0% of T2DM patients had vitamin D deficiency.
91.8% of patients in the albuminuria group were vitamin D deficient.
ACR levels were negatively correlated with 25-OH-VD levels (ρ=-0.326, P < 0.001).
Vitamin D deficiency and elevated HbA1c synergistically increased albuminuria risk (multivariate OR = 1.392, P = 0.010).
The constructed nomogram showed excellent discriminative ability with C-indices of 0.845 and 0.861 in micro- and moderate albuminuria subgroups.
Clinical Implications
The high prevalence of vitamin D deficiency in T2DM patients indicates a need for further investigation into its clinical significance.
Conclusion
Vitamin D deficiency is prevalent in T2DM patients and may contribute to albuminuria progression.
