Prognostic Factors Related to Age in a Cohort of Breast Cancer Patients from Luxembourg
Overview
This study analyzed 3,003 women diagnosed with invasive breast cancer in Luxembourg, revealing significant age-related differences in prognosis. Younger patients exhibited more aggressive tumor characteristics, while older patients showed lower overall survival rates, influenced by competing causes of mortality.
Background
Breast cancer is the most common cancer among women globally, with age being a critical factor influencing prognosis. In Luxembourg, the recent expansion of the breast cancer screening program to include younger women is noted.
Data Highlights
Age Group
5-Year Overall Survival
<40 years
91.0%
40–49 years
95.3%
50–69 years
92.3%
>=70 years
65.4%
Key Findings
Younger patients (<40 years) had a higher prevalence of triple-negative tumors (24%, P<0.001).
Five-year overall survival rates were highest in women aged 40–49 (95.3%) and 50–69 (92.3%).
Women aged ≥70 had the lowest survival rate (65.4%, P<0.001), influenced by competing causes of mortality.
Advanced stage (HR=2.92) and triple-negative subtype (HR=2.39) were linked to worse prognosis.
Mastectomy (HR=2.04) and absence of surgery (HR=8.58) were associated with poorer survival outcomes.
Clinical Implications
Understanding the distinct tumor characteristics associated with different age groups can guide clinicians in tailoring interventions.
Conclusion
Age at diagnosis significantly influences breast cancer prognosis.
