Case Study and Literature Analysis of Multidrug-Resistant Tuberculosis Affecting Breast and Uterine Adnexa - Report - MDSpire

Case Study and Literature Analysis of Multidrug-Resistant Tuberculosis Affecting Breast and Uterine Adnexa

  • By

  • Xiao-Ya Cui

  • Gui-Qing He

  • Ji-Chan Shi

  • Yi-Tong Huang

  • Zhi-Ruo Lin

  • Lian-Peng Wu

  • Xian-Gao Jiang

  • January 8, 2026

  • 0 min

Share

Clinical Report: Case Study of Multidrug-Resistant Tuberculosis in Women

Overview

This report presents a rare case of multidrug-resistant tuberculosis (MDR-TB) affecting both breast and uterine adnexa in a 33-year-old woman, highlighting the need for increased awareness and early diagnostic measures in atypical presentations.

Background

Multidrug-resistant tuberculosis (MDR-TB) poses a significant public health challenge, with approximately 400,000 cases reported globally in 2023. Extrapulmonary tuberculosis, particularly involving the breast and female genital tract, is rare, accounting for 15-20% of all TB cases, and often misdiagnosed due to nonspecific clinical manifestations. Awareness of atypical presentations is crucial for timely diagnosis and effective treatment.

Data Highlights

No numerical data available in the source material.

Key Findings

The patient presented with breast pain and distention, initially misdiagnosed as mastitis. Ultrasound findings revealed multiple lesions in the breast and adnexa, leading to delayed diagnosis. Persistent discharge and delayed wound healing post-surgery indicated a more serious underlying condition. Concurrent infections were identified in the lungs, complicating the clinical picture. Only one previous case of breast MDR-TB was reported in the literature, emphasizing the rarity of this condition.

Clinical Implications

Healthcare providers should consider MDR-TB in differential diagnoses for patients with atypical breast or adnexal lesions, especially when initial treatments fail. Early microbiological testing and drug susceptibility testing are essential to avoid misdiagnosis and ensure appropriate management.

Conclusion

This case underscores the need for heightened awareness and prompt diagnostic measures for MDR-TB in atypical presentations, which can significantly impact patient outcomes.

References

  1. World Health Organisation, Global Tuberculosis Report 2024 -- Global Tuberculosis Report 2024
  2. Open Forum Infectious Diseases, Challenges Associated with the MTB/RIF Assay -- Challenges Associated with the MTB/RIF Assay: A Review of Four Clinical Cases
  3. Open Forum Infectious Diseases, Recurrence and Development of Resistance -- Recurrence and Development of Resistance in Patients Undergoing Innovative Short-Term Treatments for Multidrug-Resistant Tuberculosis in the United States, 2022–2024
  4. Infection, Increased Likelihood of Drug-Resistant Tuberculosis -- Increased Likelihood of Drug-Resistant Tuberculosis Among IGRA-Negative Contacts: Is Preventive Treatment Warranted?
  5. Infection — Case Report of Concurrent Multi-Site Spinal Tuberculosis and Urogenital Tuberculosis Detected via 18 F-FDG-PET/CT in the Spinal TB X Cohort
  6. WHO announces landmark changes in treatment of drug-resistant tuberculosis
  7. Global tuberculosis Global tuberculosis report 202
  8. Short oral regimens for pulmonary rifampicin-resistant tuberculosis (TB-PRACTECAL): an open-label, randomised, controlled, phase 2B-3, multi-arm, multicentre, non-inferiority trial - ScienceDirect

Original Source(s)

Related Content